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Comparing IVF Success Using PPOS and GnRH Antagonist Protocols in Women with Polycystic Ovary Syndrome
Led by Hanoi General Hospital (Vietnam) · Updated on 2026-08-05
400
Participants Needed
1
Research Sites
52 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are comparing two ovarian stimulation methods used in in vitro fertilization IVF for women with polycystic ovary syndrome PCOS. The study focuses on the progestin-primed ovarian stimulation PPOS protocol and the gonadotropin-releasing hormone GnRH antagonist protocol. The goal is to evaluate and compare IVF outcomes between these two approaches in women aged 18 to 40 years diagnosed with PCOS. Participants are randomly assigned to receive ovarian stimulation either through the PPOS protocol, which combines gonadotropins with oral progestin for pituitary suppression, or the GnRH antagonist protocol that uses a gonadotropin-releasing hormone antagonist for suppression during IVF treatment. Both protocols involve controlled ovarian stimulation leading to oocyte retrieval and embryo transfer. During the study, participants will undergo ovarian stimulation, oocyte retrieval, fertilization, and embryo assessment. Researchers will track outcomes including ongoing pregnancy rates at 12 weeks after embryo transfer, number of oocytes retrieved, mature oocytes, clinical pregnancy rates, fertilization rates, usable embryos, and live birth rates up to delivery. Participants will be monitored through the IVF process to assess these outcomes and ensure adherence to the study protocol.
CONDITIONS
Brief Title
Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
Research Team
P
Phuong Duy Nguyen, MD, MSc - PI
A
Anh Huynh Phuong Nguyen, MD, MSc, Study Coordinator
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