Actively Recruiting
Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
Led by Hanoi General Hospital (Vietnam) · Updated on 2026-02-11
400
Participants Needed
1
Research Sites
127 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
CONDITIONS
Official Title
Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18-40 years
- Diagnosed with polycystic ovary syndrome (PCOS) according to the modified Rotterdam criteria (2004) (at least 2 of 3: oligo/anovulation, hyperandrogenism, or polycystic ovarian morphology on ultrasound)
- Indicated for in vitro fertilization (IVF) due to PCOS alone or PCOS with other infertility factors (e.g., tubal factor, previous failed intrauterine insemination)
- Eligible for controlled ovarian stimulation for IVF
- Husband/partner with normal sperm parameters or mild to moderate oligoasthenoteratozoospermia (OAT)
- Willing and able to provide written informed consent and comply with study procedures
You will not qualify if you...
- Uterine abnormalities that may impair implantation or pregnancy outcomes, including congenital uterine malformations, large fibroids distorting the uterine cavity, adenomyosis, or severe intrauterine pathology
- History of major ovarian or uterine surgery affecting ovarian reserve or uterine structure (e.g., ovarian cystectomy, endometriosis surgery, myomectomy, unilateral oophorectomy)
- History of recurrent pregnancy loss (3 or more spontaneous miscarriages)
- Known chromosomal abnormalities in either partner
- Inability to adhere to study protocol or follow-up procedures
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hanoi General Hospital
Hanoi, Hanoi, Vietnam, 10000
Actively Recruiting
Research Team
P
Phuong Duy Nguyen, MD, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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