Actively Recruiting
Comparison of MI Paste Plus and Resin Infiltration in White Spot Lesions Following Orthodontic Treatment
Led by University of Alberta · Updated on 2025-07-04
62
Participants Needed
1
Research Sites
174 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Dental cavities are among the most frequent diseases that affect teeth, particularly in patients who are treated with braces due to the difficulty in maintaining good oral hygiene in the presence of the mouth appliances. The white spot lesion (WSL) is the first clinical sign of cavities that presents itself as a milky-white opacity when located on the front face of the tooth. The aim to manage these early lesions focuses on promoting natural remineralization and preventing further demineralization. Various materials have been introduced for management of WSLs including MI paste and MI paste combined with fluoride (MI paste plus). Recently, a new material called resin infiltration has been found to treat these lesions with high esthetic results and great performance. According to the few numbers of in-vivo studies investigating the effectiveness of remineralization products, the aim of the current study is to clinically compare the outcome of the resin-infiltration and etching + MI paste plus to stop and improve the appearance of the WSL on front teeth in patients after treatment with braces.
CONDITIONS
Official Title
Comparison of MI Paste Plus and Resin Infiltration in White Spot Lesions Following Orthodontic Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals aged 12 to 21 years who have completed fixed orthodontic treatment lasting 12 to 36 months
- At least one white spot lesion on the front (labial) surface of upper or lower front teeth visible with or without drying
- Mild to moderate plaque accumulation and fair oral hygiene with a Simplified Oral Hygiene Index of 1.3 to 3.0
You will not qualify if you...
- Poor oral hygiene with a Simplified Oral Hygiene Index above 3.0
- Presence of enamel hypoplasia or developmental defects on the front teeth
- Any restorations on the front surfaces of upper or lower front teeth
- White spot lesions present on the front teeth before starting orthodontic treatment
- Use of remineralizing agents other than regular toothpaste within the last three months
- Allergy to milk or milk products
- Any medical, oral, or mental conditions
- Inability to read or speak English by the participant or legal guardian
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
KAYE Edmonton Clinic
Edmonton, Alberta, Canada, T6G 1Z1
Actively Recruiting
Research Team
I
Ida M Kornerup, DMD, MEd
CONTACT
N
Nancy Abdelhay, DMD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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