Actively Recruiting
Comparison of Microbiome Changes in Healthy Adults Following Ketone Ester Consumption
Led by University of California, San Francisco · Updated on 2026-01-26
20
Participants Needed
1
Research Sites
44 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn if a ketone ester can improve the content of the gut microbiome. The main questions it aims to answer are: * Does a ketone ester reduce age-related signatures in the gut microbiome? * What changes occur in the gut microbiome after consuming a ketone ester? Participants will: * Take a ketone ester every day for seven (7) days * Collect and ship stool samples within seven (7) days before, during, and within seven (7) days after the study period * Measure their ketone levels with a urine strip every day after having the drink * Answer questions about their typical diet on a normal day * Record their symptoms, if any arise
CONDITIONS
Official Title
Comparison of Microbiome Changes in Healthy Adults Following Ketone Ester Consumption
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, 18 to 40 years old at Virtual Visit 1
- Self-reported BMI between 18.5 and 39.9 kg/m2 at Virtual Visit 1
- Willing and able to follow all study procedures, including maintaining usual diet and exercise
- Has email and internet access and can participate in virtual visits
- No health conditions preventing study participation as judged by the clinician
- Understands study procedures and provides informed consent
You will not qualify if you...
- Unable to communicate in English or Spanish
- Unable to provide informed consent due to cognitive or language issues
- Hospitalized within 30 days before Virtual Visit 1
- History or presence of uncontrolled or active serious pulmonary, cardiac, liver, kidney, endocrine, blood, immune, neurological, psychiatric, or biliary disorders
- Clinically important gastrointestinal conditions affecting gut motility or study evaluation
- Known allergy or sensitivity to study product ingredients including milk protein
- Undergoing or recently treated for cancer within 2 years (except non-melanoma skin cancer)
- Used antibiotics within 60 days before Virtual Visit 1
- Extreme dietary habits or weight-loss medications/supplements used within 30 days before Virtual Visit 1
- Used medications affecting gastrointestinal function within 30 days before Virtual Visit 1
- Used ketone supplements within 30 days before Virtual Visit 1
- Female who is pregnant, planning pregnancy, lactating, or unwilling to use approved contraception during study
- Any condition that interferes with consent, compliance, study interpretation, or poses undue risk according to the clinician
AI-Screening
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Trial Site Locations
Total: 1 location
1
UCSF Wayne and Gladys Valley Center for Vision
San Francisco, California, United States, 94158
Actively Recruiting
Research Team
S
Sidharth S Madhavan, PhD
CONTACT
J
John C Newman, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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