Evaluating Minimally Invasive Surgery and Guided Biofilm Therapy with Platelet Rich Fibrin for Treating Deep Intrabony Periodontal Defects in Adults

What this Trial Is About

Researchers are evaluating the healing of intrabony periodontal defects using two approaches combined with Platelet Rich Fibrin PRF a minimally invasive surgical technique MIST and guided biofilm therapy GBT. This prospective, randomized controlled clinical study aims to compare the clinical and radiological outcomes of these treatments in patients with solitary deep intrabony periodontal defects. The main focus is to see if adding PRF improves healing and whether the surgical approach offers advantages compared to non-surgical therapy. The study includes three groups one receiving non-surgical guided biofilm therapy combined with PRF, another undergoing minimally invasive surgical treatment with PRF placed into the defect, and a control group treated only with guided biofilm therapy. The surgical group involves opening a flap to access the defect before applying PRF, while the non-surgical group applies PRF into cleaned defects without flap opening. The control group receives cleaning without PRF. Treatments are performed according to standardized protocols. Participants will be assessed at the start and six months after treatment. Clinical periodontal parameters, such as probing pocket depth, gingival recession, and clinical attachment level, will be measured. Healing will also be evaluated radiologically using standardized X-rays. The primary outcome is the change in clinical attachment level after six months. Safety, healing progress, and adherence to oral hygiene and follow-up procedures will be monitored throughout the study, which lasts at least six months after treatment.

Comparison of MIST With PRF and GBT With PRF in the Treatment of Intrabony Periodontal Defect. A Prospective RCT