Actively Recruiting
Comparison of Oral Antibiotics For Bone Infections of the Leg and Foot
Led by Michael Garron Hospital · Updated on 2026-03-27
1418
Participants Needed
3
Research Sites
409 weeks
Total Duration
On this page
Sponsors
M
Michael Garron Hospital
Lead Sponsor
U
University Health Network, Toronto
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare different classes of oral antibiotics (beta-lactam and non-beta-lactam antibiotics) for the treatment of bone infections of the leg and foot. The hypothesis is that oral beta-lactam antibiotics work as well as oral non-beta-lactam antibiotics to treat these infections. The first step is to assess whether it is possible to perform the trial by determining whether participants can be recruited and followed successfully. If the trial is proven to be possible, it will be expanded to ensure an answer to whether the two antibiotic classes work as well for the treatment of bone infections of the leg and foot.
CONDITIONS
Official Title
Comparison of Oral Antibiotics For Bone Infections of the Leg and Foot
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults over 18 years old
- Bone infection (osteomyelitis) in the lower leg or foot confirmed by a healthcare provider
- Expected need for at least 28 additional days of antibiotic treatment for the infection
- Willingness to switch to oral antibiotic therapy for the remainder of treatment
You will not qualify if you...
- Previous participation in the OSTEO trial
- More than 14 days of continuous antibiotic treatment for this infection episode before enrollment
- No suitable beta-lactam or non-beta-lactam antibiotic options due to allergy, resistance, medical contraindications, or unchangeable drug interactions
- Requirement for combination antibiotic therapy using both beta-lactam and non-beta-lactam antibiotics, except metronidazole and rifampin
- Antibiotic treatment for the same infection within the past 6 months
- Known pregnancy, planning pregnancy during the study, or breastfeeding
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
Ottawa Hospital
Ottawa, Ontario, Canada, K1Y 4E9
Not Yet Recruiting
2
Michael Garron Hospital
Toronto, Ontario, Canada, M4C 3E7
Actively Recruiting
3
University Health Network
Toronto, Ontario, Canada, M5G 2C4
Not Yet Recruiting
Research Team
C
Christopher Kandel, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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