Actively Recruiting
Comparison of Outcomes of Management of Bowel Obstruction
Led by University of Washington · Updated on 2026-05-07
550
Participants Needed
4
Research Sites
251 weeks
Total Duration
On this page
Sponsors
U
University of Washington
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Comparison of Outcomes of Management of Bowel Obstruction (COMBO) trial is a patient-level randomized trial of a short course of dexamethasone + supportive care vs supportive care alone for patients with adhesion-related small bowel obstruction (aSBO). The goal of the COMBO trial is to answer the question: Can Dexamethasone increases the proportion of patients with resolution of aSBO with non-operative management (without complication) based on an established minimal important clinical difference.
CONDITIONS
Official Title
Comparison of Outcomes of Management of Bowel Obstruction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years of age or older recruited from UWMC
- Patients presenting to surgical services through the Emergency Department with diagnosis of SBO, consulted by surgeon, and urgent or emergency operation deemed not necessary
- Diagnosis of adhesive small bowel obstruction established by CT findings, signs and symptoms consistent with SBO, and adhesions from prior abdominopelvic surgery as likely cause
- Ability to provide written or electronic informed consent in English and answer teach-back questions
You will not qualify if you...
- Signs and symptoms of peritonitis with emergency operation planned
- Planned urgent operation within the next 12 hours
- Allergy to dexamethasone
- Surgery within prior 6 weeks
- Unable or unwilling to return or be contacted for and/or complete research surveys
- Currently incarcerated in a detention facility or in police custody at baseline/screening
- Individuals with latent infections who have an increased risk of infection
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 4 locations
1
Columbia University Medical Center
New York, New York, United States, 10032
Actively Recruiting
2
Harborview Medical Center
Seattle, Washington, United States, 98104
Actively Recruiting
3
UW Medical Center - Northwest
Seattle, Washington, United States, 98133
Actively Recruiting
4
University of Washington Medical Center Montlake
Seattle, Washington, United States, 98195
Actively Recruiting
Research Team
K
Kelsey Pullar, MPH
CONTACT
E
Erin Fannon
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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