Actively Recruiting
Comparison of Palatal Wound Healing in Diabetic and Non-diabetic Patients
Led by Universidade Estadual Paulista Júlio de Mesquita Filho · Updated on 2024-08-06
50
Participants Needed
2
Research Sites
179 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to characterize and compare the closure of open wounds in the palatal mucosa of diabetic and non-diabetic patients, evaluate clinical, patient-centered and immunological parameters as well as wound microbiome composition.
CONDITIONS
Official Title
Comparison of Palatal Wound Healing in Diabetic and Non-diabetic Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older with good oral hygiene, shown by plaque and gingival indices below 25%
- No morphological or pathological conditions on the palatal donor area
- Patients requiring tooth extraction and ridge preservation
- Teeth included in the study and adjacent teeth must not have periodontal insertion loss
- Patients who provide informed consent after being fully informed about the study
- Diabetic patients with type 2 diabetes for over 5 years using oral hypoglycemic agents or insulin and HbA1c between 61 6.1% and 8.5%
- Non-diabetic patients with HbA1c below 6.1%
You will not qualify if you...
- Patients with systemic illnesses contraindicating surgery such as cardiovascular disease, blood disorders, immunodeficiency, or diabetes other than type 2
- Patients taking medications that affect wound healing or contraindicate surgery
- Current smokers
- Pregnant or breastfeeding patients
- Patients who have had periodontal surgery in the study area
- Patients with opportunistic oral lesions, especially on the palate
- Use of dental prosthesis covering the palate
- Thin palatal mucosa approximately 2.0 mm thick
AI-Screening
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Trial Site Locations
Total: 2 locations
1
College of Dentistry - São José dos Campos, Sao Paulo State University
São José dos Campos, São Paulo, Brazil, 12245-310
Actively Recruiting
2
Mauro Pedrine Santamaria and Ana Carolina Ferreira Bonafe
São José dos Campos, São Paulo, Brazil, 12245000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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