Evaluating 3D Versus Conventional Colonoscopy for Adenoma Detection in Adults 40 and Older With Positive Fecal Immunochemical Test

What this Trial Is About

Researchers are evaluating whether 3D colonoscopy improves the detection of precancerous adenomas compared to conventional 2D colonoscopy in people with positive fecal immunochemical tests FIT, who are at higher risk for colorectal cancer. Adenoma detection rate ADR is a key quality measure linked to colorectal cancer risk, and this study aims to see if 3D imaging can better detect flat or non-polypoid lesions that are often missed during standard colonoscopy. Participants will be randomly assigned to receive either 3D colonoscopy using a specialized 3D imaging device or traditional 2D colonoscopy. The study involves multiple centers and uses a double-blind design, ensuring unbiased results. The main focus is on adenoma detection within 30 minutes of the procedure, with additional measures including detection rates of flat adenomas, proximal adenomas, sessile serrated lesions, advanced adenomas, polyps, and counts of adenomas and polyps per colonoscopy. During the study, participants will undergo colonoscopy examinations with either the 3D or 2D method. Researchers will monitor adenoma detection and related outcomes during the procedure. The trial is sponsored by National Taiwan University Hospital and aims to provide detailed comparisons of colonoscopy quality indicators. The study is planned to start in January 2024 and continue until February 2027.

Comparison of the Performance Between Conventional Colonoscopy and 3D Colonoscopy in Positive Fecal Immunochemical Test Group