Comparison of the Train-of-Four Ratio and Modified Train-of-Four Ratio During Reversal of Deep Neuromuscular Blockade With Sugammadex

What this Trial Is About

Researchers are evaluating the use of two different methods to monitor recovery from deep neuromuscular blockade during surgery. This study focuses on comparing the traditional train-of-four ratio (cTOFR) and a modified train-of-four ratio (mTOFR) to see which better indicates safe extubation when reversing blockade with the drug sugammadex. The study is observational and addresses concerns about postoperative complications caused by residual neuromuscular block after anesthesia. Participants will undergo anesthesia involving rocuronium to induce muscle relaxation, followed by monitoring with the TOFscan device, which measures neuromuscular function. Sugammadex will be administered to reverse the blockade, and researchers will record classical and modified TOF ratios until full recovery is confirmed. The anesthesia process includes specific medication dosing, monitoring with multiple devices, and maintaining muscle relaxation at targeted levels during surgery. During the study, participants will be closely monitored with ECG, blood pressure, oxygen levels, brain activity, and acceleromyography. Neuromuscular function will be assessed repeatedly until reversal is complete. Data on drug use, TOF ratios, and recovery times will be collected. The primary outcome is the time measured up to 15 minutes, with a secondary outcome at 30 minutes. Participants will be observed until both TOF ratios reach 100%, ensuring complete neuromuscular recovery.

Comparison of the Performances of the cTOFR and the mTOFR During Reversal of Deep Neuromuscular Blockade With Sugammadex