Actively Recruiting
Comparison of the Performances of the cTOFR and the mTOFR During Reversal of Deep Neuromuscular Blockade With Sugammadex
Led by Ankara University · Updated on 2026-02-12
199
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
It is known that deep neuromuscular block improves surgical conditions, especially during laparoscopic abdominal surgery. Based on this, in the Perioperative Neuromuscular Blockade Management guide published by the ESAIC association in 2022, it is recommended to deepen the level of neuromuscular blockade in cases where surgical conditions need to be improved. Sugammadex should be used to quickly and reliably reverse deep neuromuscular blockade. TOFScan, a 3-dimensional acceleromyograph for neuromuscular monitoring, has become widely used in recent years. With this monitor, it has been shown that in addition to the classical train-of-four ratio (cTOFR), the modified train-of-four ratio (mTOFR) can be used during the spontaneous recovery of nondepolarizing neuromuscular blockade. In a study conducted by Schmartz et al. in 2021, it was shown that mTOFR, which is the ratio of T4 to the reference stimulus, was compiled later than cTOFR. Therefore, it is suggested that the mTOFR value is a better determinant for safe extubation.
CONDITIONS
Official Title
Comparison of the Performances of the cTOFR and the mTOFR During Reversal of Deep Neuromuscular Blockade With Sugammadex
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 64 years
- Body mass index (BMI) between 18.5 and 24.9
You will not qualify if you...
- Liver and kidney disease
- Not willing to consent to participate
- Emergency surgeries
- Muscle diseases
- Allergy to rocuronium or sugammadex
- Predicted difficult mask ventilation or intubation
- Pregnant or breastfeeding women
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ankara University
Ankara, Altındağ, Turkey (Türkiye), 06230
Actively Recruiting
Research Team
H
Hatice Güneş Yeşilova, 1
CONTACT
M
Menekşe Özçelik, 2
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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