Actively Recruiting
Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic Stroke
Led by Jinling Hospital, China · Updated on 2025-11-18
810
Participants Needed
2
Research Sites
133 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to conduct a multicenter, prospective, randomized clinical trial to scientifically evaluate the safety and efficacy of different perioperative sedation methods during endovascular thrombectomy in acute ischemic stroke patients with large vessel occlusion in the anterior circulation.
CONDITIONS
Official Title
Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Presenting with symptoms of acute ischemic stroke
- Confirmed occlusion of the anterior circulation arteries by CTA or MRA
- Randomization completed within 24 hours of symptom onset or last known well time
- Pre-stroke modified Rankin Scale score of 2 or less
- NIH Stroke Scale score of 6 or more at randomization
- ASPECTS score of 3 or higher
- Signed informed consent form
You will not qualify if you...
- Pregnant or breastfeeding women
- Allergy to contrast agents or nitinol devices
- Allergy to midazolam or other benzodiazepines
- Allergy to dexmedetomidine or its components
- Planned general anesthesia for the thrombectomy
- Uncontrolled high or low blood pressure (systolic >185 mmHg or <90 mmHg, diastolic >110 mmHg or <60 mmHg)
- Second- or third-degree heart block or slow heart rate below 50 beats per minute
- Major surgery or serious trauma within the past 14 days
- Known bleeding disorders or abnormal blood clotting tests
- Blood glucose less than 2.8 or greater than 22.2 mmol/L
- Severe kidney failure or dialysis treatment
- Life expectancy under 1 year
- Severe agitation or seizures
- Signs of central nervous system vasculitis
- Pre-existing neurological or mental disorders affecting evaluation
- Unwillingness to attend follow-up within 90 days
- Participation in other interventional randomized clinical trials
- Evidence of brain bleeding on CT or MRI
- Cerebellar infarction with mass effect and ventricle compression
- Untreated or incompletely treated brain aneurysms or vascular malformations
- Blockage of multiple or both sides of brain vessels
- Brain tumors causing mass effect
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Jinling Hospital, Medical School of Nanjing University
Nanjing, None Selected, China
Actively Recruiting
2
The General Hospital of Western Theater Command PLA
Chengdu, China
Actively Recruiting
Research Team
R
Rui Liu
CONTACT
X
Xinfeng Liu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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