Actively Recruiting
Comparison of I-124 PET/CT for the Diagnosis of Thyroid Cancer
Led by Thomas Hope · Updated on 2026-04-22
62
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
Sponsors
T
Thomas Hope
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
Persons diagnosed with thyroid cancer are often treated initially with a thyroidectomy, which is followed by ablation using Iodine-131, a therapy which has been shown to be effective and safe. Imaging of metastatic thyroid cancer has been performed with whole body I-131 and Iodine 123 (I-123) imaging for many decades and use I-123 for staging studies. Iodine 124 (I-124) is a radioisotope of iodine which emits a positron and is imaged using PET (positron emission tomography). This is a single arm prospective trial that evaluates the ability of Iodine-124 (I-124) to detect metastatic thyroid cancer compared to non-interventional, usual care I-123 and I-131 images.
CONDITIONS
Official Title
Comparison of I-124 PET/CT for the Diagnosis of Thyroid Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 13 years or older
- Histopathologically confirmed differentiated thyroid cancer with clinical concern for metastatic disease
- Metastatic disease seen on I-123 SPECT, FDG PET, CT scan, or ultrasound
- Elevated thyroglobulin after total thyroidectomy or presence of thyroglobulin antibodies if thyroglobulin is undetectable
- Meets criteria for ATA intermediate or high-risk thyroid cancer planning I-131 treatment, or metastatic disease considering localized therapy such as surgery or radiation
- Undergone total thyroidectomy
- Planned I-123 imaging within 45 days after enrollment
- Ability to understand and willing to sign informed consent
You will not qualify if you...
- Unlikely to comply with study procedures, restrictions, and requirements as judged by the Investigator
- Known pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of California, San Francisco
San Francisco, California, United States, 94122
Actively Recruiting
Research Team
M
Maya Aslam
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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