Actively Recruiting
Comparison of Phaco Surgery With Goniosynechialysis Versus Trabeculectomy in Glaucoma Treatment
Led by University of Medicine and Pharmacy at Ho Chi Minh City · Updated on 2025-09-11
82
Participants Needed
1
Research Sites
118 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn whether phacoemulsification combined with goniosynechialysis (Phaco-GSL) is as effective and safe as trabeculectomy in treating patients with primary angle-closure glaucoma. The main questions it aims to answer are: * Does Phaco-GSL provide similar or better intraocular pressure (IOP) control compared to trabeculectomy? * What are the rates of postoperative complications or adverse events between the two surgical approaches? * How do the two procedures compare in terms of visual acuity recovery and need for glaucoma medications? Researchers will compare Phaco-GSL to trabeculectomy to determine which procedure offers better overall outcomes for patients with angle-closure glaucoma. Participants will: Be randomly assigned to undergo either Phaco-GSL or trabeculectomy Attend scheduled follow-up visits at regular intervals (e.g., 1 week, 1 month, 3 months, 6 months, 12 months) for eye exams and pressure checks
CONDITIONS
Official Title
Comparison of Phaco Surgery With Goniosynechialysis Versus Trabeculectomy in Glaucoma Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 40 years or older
- Peripheral anterior synechiae (PAS) greater than 180 degrees
- Glaucomatous optic neuropathy with visual field loss
- Intraocular pressure (IOP) above 21 mmHg despite medication
- Ability to give consent and comply with follow-up visits
- Cataract grade 1 to 3 according to LOCS III
- Best corrected visual acuity (BCVA) of 0.3 logMAR or better (20/40 Snellen or worse)
You will not qualify if you...
- Very advanced glaucoma with only light perception vision
- Secondary causes of angle-closure glaucoma
- Prior ocular surgeries or laser peripheral iridotomy (PI)
- Allergy to 5-fluorouracil (5-FU) if used after surgery
- Irreversible corneal disease
- Chronic use of corticosteroids
- Poor compliance with follow-up
- Cataract grade 4 or 5 according to LOCS III
- Phacomorphic, phacolytic, or subluxated cataracts
AI-Screening
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Trial Site Locations
Total: 1 location
1
HCMC University of Medicine and Pharmacy
Ho Chi Minh City, Vietnam
Actively Recruiting
Research Team
H
Hai Thanh Le, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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