Study Comparing Standard and Modified High-Flow Tracheal Oxygen to T-Piece During Spontaneous Breathing Trials in Mechanically Ventilated Adults

What this Trial Is About

Researchers are investigating different methods of high-flow tracheal oxygen delivery during spontaneous breathing trials SBT in mechanically ventilated patients. The study aims to compare the physiological effects of standard and modified high-flow tracheal oxygen tubes against the traditional T-piece method. This research focuses on improving the assessment of extubation tolerance by testing a modified oxygen tube designed to increase airway pressure and resistance, potentially enhancing lung function during SBT. The trial involves five interventions modified high-flow tracheal oxygen at flow rates of 40 and 60 liters per minute, standard high-flow tracheal oxygen at the same flow rates, and the T-piece method. Each method will be applied to patients undergoing spontaneous breathing trials to assess differences in physiological responses. The modified tube has a smaller expiratory end diameter to increase expiratory resistance and airway pressure, aiming to simulate the effects of high-flow nasal oxygen more closely. Participants will be monitored from enrollment through a 4-hour treatment period during each intervention. Key assessments include measuring mean expiratory airway pressure, positive end-expiratory pressure, and changes in end-expiratory lung volume. Secondary measures such as respiratory rate, tidal volume, oxygen saturation, and various respiratory muscle pressures will also be recorded. This data will help evaluate the impact of each oxygen delivery method on respiratory workload and lung function during weaning from mechanical ventilation.

Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials