Actively Recruiting
Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials
Led by Jian-Xin Zhou · Updated on 2025-03-21
20
Participants Needed
1
Research Sites
43 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Spontaneous breathing trials (SBT) are essential for assessing extubation tolerance, yet optimal approaches are debated. High-flow nasal oxygen offers benefits like precise oxygen delivery, flow-related positive end-expiratory pressure generation and improved lung function. While high-flow tracheal oxygen can also be used as an SBT method, it has reduced physiological effects due to bypassing the upper airway with a more open circuit. To enhance this limitation, investigators developed a modified high-flow tracheal oxygen tube with a smaller expiratory end diameter to increase expiratory resistance and airway pressure. This is a prospective randomized crossover study that aims to compare the physiological effects of standard and modified high-flow tracheal oxygen versus T-piece during SBT.
CONDITIONS
Official Title
Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Mechanical ventilation for more than 24 hours
- Considered by the physicians for readiness to wean and ready for spontaneous breathing trials
You will not qualify if you...
- Age younger than 18 years old
- Pregnancy
- Hemodynamic instability (mean arterial pressure <60 mmHg, heart rate >140 or <60 bpm)
- Respiratory and oxygenation instability (respiratory rate >35 bpm or oxygen saturation <90%)
- Neuromuscular diseases or phrenic nerve injury
- Recent trauma or surgery to the trachea, esophagus, neck, chest, or stomach
- Pneumothorax or placement of a chest drainage
- Contraindication to electrical impedance tomography (implantable defibrillator)
- Anticipating withdrawal of life support
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Beijing Shijitan Hospital
Beijing, Beijing Municipality, China, 100038
Actively Recruiting
Research Team
J
Jian-Xin Zhou, MD, PhD
CONTACT
S
Shan-Shan Xu, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
5
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