Actively Recruiting
Comparison of Post Operative Analgesia Duration in Lower Abdominal Surgeries Receiving Ultrasound-Guided TAP Block With Bupivacaine and Dexmedetomidine vs Dexamethasone
Led by Pakistan Institute of Medical Sciences · Updated on 2026-04-02
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating post operative pain relief methods for patients undergoing lower abdominal surgeries. This trial focuses on comparing the duration of pain control using ultrasound-guided Transversus Abdominis Plane (TAP) block with two different additives: Dexmedetomidine and Dexamethasone. The study aims to determine which combination provides longer lasting analgesia after surgery. Participants will receive a TAP block bilaterally with 20 ml of 0.25% Bupivacaine combined either with 0.5 mcg/kg of Dexmedetomidine or with 4 mg of Dexamethasone. This randomized trial includes two groups each receiving one of these drug combinations during surgery. The goal is to assess how each additive affects the duration of pain relief after the procedure. During the study, researchers will monitor when patients first request additional pain medication after surgery to measure the effectiveness of the analgesia. Participants will be assessed for pain relief duration and any related outcomes. The trial will run from March 2026 to June 2026 and includes adult patients aged 18 to 60 undergoing lower abdominal surgeries. Safety and efficacy are evaluated through this single-blind, phase 4 study.
CONDITIONS
Brief Title
Comparison of Post Operative Analgesia in Patients Undergoing Lower Abdominal Surgeries Receiving Ultrasound Guided Block With Dexmetomidine vs Dexmethasone
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 60 years
- ASA physical status I or II
- Body mass index between 25 and 35 kg/m2
- Undergoing lower abdominal surgeries below L2-L3 levels
You will not qualify if you...
- Infection at block site
- Blood clotting disorder (coagulopathy)
- Use of antiplatelet medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - During surgery and immediate post-operative period
Participants receive an ultrasound-guided TAP block with either Bupivacaine and Dexmedetomidine or Bupivacaine and Dexamethasone for post-operative pain relief following lower abdominal surgery.
1 treatment visit (in-person)
Duration - Until first demand for rescue analgesia post-surgery
Participants are monitored for the duration of post-operative analgesia and need for rescue pain medication.
Approximately 1 to 2 visits post-surgery
Trial Site Locations
Total: 1 location
1
Pakistan Institute of Medical Sciences Islamabad
Islamabad, Federal, Pakistan, 44000
Actively Recruiting
Research Team
D
Department of Anesthesia Principal Investigator
M
Muhammad Haroon Anwar Study Coordinator, MBBS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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