Postoperative Pain Relief Comparison of Intrathecal Morphine and Bi-level Erector Spinae Plane Block in Adult Liver Donors

What this Trial Is About

Researchers are evaluating the effects of two regional anesthesia techniques, intrathecal morphine and bi-level erector spinae plane block, on postoperative pain relief in living liver donors. The study focuses on improving pain management after donor hepatectomy, which is crucial for donor recovery, quality of life, and reducing the risk of chronic pain. This trial compares these methods to determine which better controls pain and reduces opioid use after surgery. Participants will receive either an intrathecal injection of 300 mcg morphine at the L3-L4 or L4-L5 spinal level or a bi-level erector spinae plane block. The block involves ultrasound-guided injections of 0.25% bupivacaine at two levels on both sides of the spine. Both groups will also receive intravenous meperidine during surgery and dexketoprofen twice daily after surgery as part of multimodal pain control. During the study, pain scores on the day of surgery will be measured to assess analgesic effectiveness. Researchers will also monitor opioid use during and after surgery to evaluate pain management. The trial involves randomized, double-blind assignment to treatment groups and includes adults aged 18 to 65 years with specific health criteria. The study is sponsored by Ankara Etlik City Hospital and is expected to run until July 2026.

Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors