Actively Recruiting
Comparison of the Postoperative Analgesic Effects of Intrathecal Morphine and Bi-level Erector Spinae Plane Block in Liver Transplantation Donors
Led by Ankara Etlik City Hospital · Updated on 2025-08-19
60
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of two regional anesthesia techniques, intrathecal morphine and bi-level erector spinae plane block, on postoperative pain relief in living liver donors. The study focuses on improving pain management after donor hepatectomy, which is crucial for donor recovery, quality of life, and reducing the risk of chronic pain. This trial compares these methods to determine which better controls pain and reduces opioid use after surgery. Participants will receive either an intrathecal injection of 300 mcg morphine at the L3-L4 or L4-L5 spinal level or a bi-level erector spinae plane block. The block involves ultrasound-guided injections of 0.25% bupivacaine at two levels on both sides of the spine. Both groups will also receive intravenous meperidine during surgery and dexketoprofen twice daily after surgery as part of multimodal pain control. During the study, pain scores on the day of surgery will be measured to assess analgesic effectiveness. Researchers will also monitor opioid use during and after surgery to evaluate pain management. The trial involves randomized, double-blind assignment to treatment groups and includes adults aged 18 to 65 years with specific health criteria. The study is sponsored by Ankara Etlik City Hospital and is expected to run until July 2026.
CONDITIONS
Brief Title
Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18-65 years
- American Society of Anesthesiologists (ASA) score I-II
- Body Mass Index (BMI) between 18-30 kg/m2
You will not qualify if you...
- Patients under 18 and over 65 years of age
- ASA score III and above
- Patients with a history of bleeding diathesis
- Body Mass Index (BMI) below 18 or above 30 kg/m2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - On the operation day
Participants receive either an intrathecal injection of morphine or a bi-level erector spinae plane block during liver transplantation surgery, with additional multimodal analgesia provided postoperatively.
1 intraoperative treatment session and postoperative assessments on the same day
Trial Site Locations
Total: 1 location
1
Ankara Etlik City Hospital
Altındağ, Ankara, Turkey (Türkiye), 06000
Actively Recruiting
Research Team
A
Atakan Sezgi
J
Jülide Ergil
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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