Actively Recruiting
Comparison of Postoperative Analgesic Efficacy of Transversus Abdominis Plane Block (TAP) and Modified Thoracoabdominal Nerve Block (M-TAPA) in Patients Undergoing Laparoscopic Cholecystectomy
Led by Ankara Etlik City Hospital · Updated on 2025-06-04
80
Participants Needed
1
Research Sites
1 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the postoperative pain relief effectiveness of two nerve block methods, the Transversus Abdominis Plane (TAP) Block and the Modified Thoracoabdominal Nerve Block with a Pericostal Approach (M-TAPA), in patients undergoing laparoscopic cholecystectomy. This surgery is commonly used to treat gallstone disease but can cause moderate to severe pain afterward. The study aims to compare these two nerve blocks to standard pain management, as nerve blocks may reduce opioid use and related side effects like nausea, vomiting, and respiratory issues. Participants receive either the TAP Block or the M-TAPA nerve block before surgery under ultrasound guidance while lying on their backs. Both blocks involve injecting bupivacaine near abdominal nerves on both sides using specific ultrasound techniques to guide needle placement. Patients who do not agree to nerve blocks receive the usual intravenous pain treatments. The study randomizes patients to one of the two nerve block groups and uses a triple-blind design. During the study, patients' pain levels are measured over the first 24 hours after surgery. Researchers also monitor the amount of remifentanil (a pain medication) used during surgery. Participants are evaluated for pain control effectiveness and any side effects. The study includes adult patients aged 18 to 65 years undergoing elective laparoscopic cholecystectomy, with follow-up through the immediate postoperative period to assess pain outcomes and medication use.
CONDITIONS
Brief Title
Comparison of Postoperative Analgesic Efficacy of Transversus Abdominis Plane Block (TAP) and Modified Thoracoabdominal Nerve Block (M-TAPA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years
- American Society of Anesthesiologists (ASA) physical status I, II, or III
- Body mass index between 18 and 30 kg/m2
- Scheduled for elective laparoscopic cholecystectomy surgery
You will not qualify if you...
- Under 18 years or over 65 years
- ASA score IV or higher
- Presence of advanced co-morbidities
- History of bleeding disorders
- Refusal of the nerve block procedure
- Chronic use of opioids or analgesics
- Emergency surgery cases
- Infection at the block injection site
- Known allergy to local anesthetics
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants receive either Transversus Abdominis Plane (TAP) Block or Modified Thoracoabdominal Nerve Block (M-TAPA) under ultrasound guidance before laparoscopic cholecystectomy surgery and anesthesia induction.
1 visit (in-person)
Duration - First 24 hours after surgery
Participants are monitored for pain and analgesic efficacy during the first 24 hours after surgery.
1 follow-up visit (in-person)
Trial Site Locations
Total: 1 location
1
Ankara Etlik City Hospital
Yenimahalle, Ankara, Turkey (Türkiye), 06170
Actively Recruiting
Research Team
M
MÜRÜVVET TAŞKIR TURAN, MD
M
MUSA ZENGİN, Associate Professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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