Actively Recruiting
Comparison of Proton and Photon Radiotherapy of Brain Tumors (ProtoChoice-Hirn)
Led by Technische Universität Dresden · Updated on 2024-12-16
555
Participants Needed
2
Research Sites
691 weeks
Total Duration
On this page
Sponsors
T
Technische Universität Dresden
Lead Sponsor
G
German Cancer Research Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
This protocol compares the toxicity of radiotherapy or radiochemotherapy applied with different radiation modalities - protons or photons. Patients with different kinds of brain tumours and foreseen high-dose radiotherapy can be included. The hypothesis of the trial is that the rate of chronic toxicity 1 year after the end of radiotherapy is 15% lower after proton compared to photon treatment.
CONDITIONS
Official Title
Comparison of Proton and Photon Radiotherapy of Brain Tumors (ProtoChoice-Hirn)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of primary brain tumor including gliomas (low or high grade), intracerebral meningiomas, pituitary adenomas, craniopharyngioma, or other rare brain tumors
- Brain tumor recurrence without prior irradiation
- Brain tumor recurrence with prior irradiation greater than 40 Gy in the overlapping tumor region
- Medical indication for radiotherapy or radiochemotherapy
- Both proton and photon therapy medically possible (no standard indication exclusively for one)
- Age 18 years or older
- General health status ECOG 2 or better, outpatient treatment possible
- Indication for high-dose radiotherapy or radiochemotherapy (except group 4)
- Ability and capacity to provide written informed consent
You will not qualify if you...
- Inability to provide written informed consent
- Diagnosis of cerebral lymphomas
- Presence of brain metastases
- Very small tumors such as acoustic neuromas or very small recurrences where proton therapy is not an alternative to stereotactic radiotherapy
- Inability to undergo MRI planning (e.g., contraindications to MRI)
- Lack of patient compliance
- Limited possibility for reproducible positioning due to severe mobility restrictions
- Inability to attend regular follow-up visits as required by the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University Hospital Carl Gustav Carus, Department of Radiotherapy and Radiation Oncology
Dresden, Germany, 01307
Actively Recruiting
2
University Hospital Gießen and Marburg, Department of Radiotherapy and Radiation Oncology
Marburg, Germany, 35043
Actively Recruiting
Research Team
M
Mechthild Krause, Prof.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
8
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