Comparing Radical Prostatectomy and Precision Prostatectomy for Men with Low- and Intermediate-risk Prostate Cancer A Randomized Treatment Study

What this Trial Is About

This trial investigates treatments for men with low- and intermediate-risk prostate cancer, comparing two surgical approaches radical prostatectomy RP and precision prostatectomy PP. RP is the current standard surgery that removes the entire prostate and surrounding tissue but often leads to side effects like erectile dysfunction and urinary incontinence. PP is a newer technique that removes most prostate tissue while preserving nerves and structures important for sexual function and continence, aiming to improve quality of life without sacrificing cancer control. Participants will be randomly assigned to receive either standard RP or PP surgery. RP involves complete removal of the prostate and nearby tissue, while PP preserves some prostate tissue and nerves on the side opposite the main cancer lesion. Both surgeries follow similar procedures, require no extra equipment, and are covered by standard health insurance. Outcomes will be measured 12 months after surgery, focusing on sexual health and urinary continence. During the study, participants sexual function will be assessed using the Sexual Health Inventory for Men SHIM score before surgery and at 3 and 12 months after surgery. Urinary continence will also be measured at 12 months by the number of pads used per day. Oncological outcomes will be evaluated by whether additional prostate cancer treatment is needed within 12 months. The study aims to show that PP offers better functional recovery without worse cancer control compared to RP.

A Comparison of Radical Prostatectomy and Precision Prostatectomy in Low- and Intermediate-risk Prostate Cancers.