Actively Recruiting
Comparison of RCA and RACD in Extra-renal Purification by SLED
Led by Groupe Hospitalier Sud Ile-de-France · Updated on 2025-06-10
138
Participants Needed
1
Research Sites
195 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
One of the main RRT issues is anticoagulation of the ECC, because blood contact with biomaterials causes bio-incompatibility reactions, including activation of the coagulation cascade. Based on Regional Citrate Anticoagulation (RCA) protocols, an ionized calcium (Ca-ion) concentration around 0.25 to 0.35mmol / L prevents fibrino formation and allows anticoagulation for the ECC. During RCA, metabolic side effects may occur due to systemic flow of citrate. Our postulate is that reduction of ionized calcemia related to the use of a calcium-free dialysate and haemofilter performance makes it possible to avoid citrate infusion. Our study aim to compare intermittent RRT using 4% Citrate infusion and without Citrate.
CONDITIONS
Official Title
Comparison of RCA and RACD in Extra-renal Purification by SLED
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All patients requiring Renal Replacement Therapy
You will not qualify if you...
- Age under 18 years
- Pregnancy
- Blood calcium level (hypercalcemia) of 3 mmol/L or higher
- Major under guardianship
- Major deprived of freedom
- Unable to provide free and informed consent
- Presence of bleeding or coagulation disorders
- Platelet count less than 30 G/L
- Receiving curative anticoagulation treatment
- Severe liver disease with Prothrombin rate less than 30%
- Deficiency in coagulation factors
- Not registered with a social security system
AI-Screening
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Trial Site Locations
Total: 1 location
1
Groupe Hospitalier Sud Ile-de-France
Melun, France, 77000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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