Actively Recruiting
A Comparison of Renal versus Limb NIRS Sensors for Predicting Acute Kidney Injury After Cardiac Surgery
Led by University of Utah · Updated on 2025-08-17
100
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of Near Infrared Spectroscopy (NIRS) to predict acute kidney injury (AKI) in adult patients undergoing cardiac surgery with cardiopulmonary bypass. AKI is a common and serious complication after such surgeries, leading to increased hospital stays, costs, and mortality. This study aims to compare the effectiveness of NIRS sensors placed on the skin over the kidney versus sensors placed on the limbs for predicting AKI. The research is conducted by the University of Utah's anesthesiology department. Participants will have NIRS sensors placed on the skin over their kidney, as located by ultrasound, and on the muscles of their arm and thigh before surgery. If a patient has had a right nephrectomy, the sensor will be placed over the left kidney. Additional sensors will be placed on the forehead to measure brain oxygen levels during surgery. The study observes how well these sensor placements predict AKI from the day of surgery up to seven days afterward. During the study, participants will undergo ultrasound measurements to determine the depth of kidney and muscle tissue before sensor placement. Researchers will monitor oxygen levels in various tissues throughout surgery and track outcomes such as AKI development, ventilator times, length of hospital stay, and in-hospital mortality up to three months. Hemodynamic data including blood pressure, oxygen delivery, vasopressor use, and anemia during surgery will also be recorded. The total observation period extends from surgery through hospital discharge and follow-up for up to three months.
CONDITIONS
Brief Title
A Comparison of Renal vs Limb NIRS for Predicting Cardiac Surgery Associated Acute Kidney Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult cardiac surgery patients undergoing procedures requiring cardiopulmonary bypass
- Patients at risk for acute kidney injury
- Age 18 years or older
- Ability to provide informed consent
You will not qualify if you...
- Age less than 18 years
- Preoperative end-stage kidney disease requiring dialysis
- Emergency surgery
- Patient refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants have NIRS sensors placed on the skin overlaying the kidney, arm, and thigh before cardiac surgery to monitor tissue oxygenation during the procedure.
1 visit (in-person, during surgery)
Duration - Up to 24 hours
Participants undergo cardiac surgery with cardiopulmonary bypass while monitored by NIRS sensors to assess hemodynamic changes.
Continuous monitoring during surgery and immediate post-operative period
Duration - Up to 3 months
Participants are monitored for development of acute kidney injury and other outcomes from post-operative day 0 to day 7, with additional observation up to 3 months for hospital stay and mortality outcomes.
Multiple follow-up visits during hospital stay and up to 3 months post-surgery
Trial Site Locations
Total: 1 location
1
University of Utah
Salt Lake City, Utah, United States, 84132
Actively Recruiting
Research Team
N
Natalie Silverton, MD
N
Natalie Bennion, MPH
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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