Comparison of Segmentectomy Versus Lobectomy for Lung Adenocarcinoma ≤ 2cm With Micropapillary and Solid Subtype Positive by Frozen Section: A Prospective, Observational, Multicenter Cohort Study

What this Trial Is About

This research aims to compare the recurrence-free survival and overall survival between lobectomy and segmentectomy in patients with lung adenocarcinoma tumors 2 cm or smaller that have micropapillary and solid subtypes, as identified by intraoperative frozen sections. The study addresses the need for evidence on whether segmentectomy is appropriate for invasive adenocarcinoma with these features. It is a prospective, multicenter cohort study conducted to evaluate these surgical approaches in such patients. Participants will undergo either lobectomy or segmentectomy, both performed with systemic or selective hilar and mediastinal lymph node dissection involving at least three mediastinal lymph node stations depending on the side of the lung. In segmentectomy, if the tumor is located at an inter-segment plane and the resection margin is insufficient, a combined segmentectomy will be performed after evaluation. The distance from the tumor edge to the resection margin will be assessed intraoperatively in both procedures to confirm absence of cancer cells before completing surgery. During the study, patients will be monitored for recurrence-free survival over five years, with overall survival also measured at five years. Pulmonary function and organ function will be assessed to confirm eligibility for surgery. The study involves careful intraoperative frozen section analysis to guide surgical decisions and ensure clear resection margins. Participants will be followed to evaluate long-term outcomes of these surgical treatments for lung adenocarcinoma.

Comparison of Segmentectomy Versus Lobectomy for Lung Adenocarcinoma ≤ 2cm