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Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging
Led by University of Pennsylvania · Updated on 2020-07-16
20
Participants Needed
1
Research Sites
156 weeks
Total Duration
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AI-Summary
What this Trial Is About
The purpose of this study is to test different methods of preparation that can be used prior to a test called an FDG PET/CT scan. FDG PET/CT scans are routinely done for evaluation of heart inflammation. Standard preparation for the scan includes a ketogenic (high fat and low carbohydrate) diet for 24 hours and overnight fasting to help suppress the amount of sugar taken up in the heart muscle. However, Investigator still do not know if this preparation is the most effective method. So the Investigator, want to investigate alternative methods for decreasing the amount of sugar uptake seen in the heart during FDG PET/CT scan, thus, investigator will have participants try up to 3 different methods of preparation prior to the FDG PET/CT scans to see which type of preparation works the best.
CONDITIONS
Official Title
Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients, at least 18 years of age
- No history of cardiovascular disease, including hypertension, hyperlipidemia, coronary artery disease, cardiac surgery, or arrhythmias
- No history of diabetes mellitus, chronic liver disease, or kidney disease
- Must provide written informed consent after being informed about the investigational nature of the study
You will not qualify if you...
- Pregnant or breastfeeding females at the time of screening
- Female participants of child-bearing potential must have a negative urine or serum pregnancy test before the first study visit
- Inability to tolerate imaging procedures as determined by the investigator or treating physician
- Serious or unstable medical or psychological conditions that could affect safety or participation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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