Actively Recruiting
Comparison of Skin Prick Testing, Extract-specific IgE Antibody Testing and Component Resolved Diagnosis in Diagnosing of Legume Allergy
Led by University Hospital Pilsen · Updated on 2026-04-09
100
Participants Needed
1
Research Sites
286 weeks
Total Duration
On this page
Sponsors
U
University Hospital Pilsen
Lead Sponsor
M
MacroArray Diagnostics GmbH
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study is aimed at improving the diagnosis of food allergy, specifically allergy to commonly consumed legumes such as peas, lentils, chickpeas or green beans. Patients suspected of allergy to these legumes will be examined using traditional methods of IgE-mediated allergy diagnosing (skin prick test, testing for specific IgE antibodies against food extract), but also by testing for specific IgE antibodies against relevant allergenic molecules of these legumes. The results of performed tests will be compared with the result of the oral food challenge, which is considered to be the gold standard of food allergy diagnosis.
CONDITIONS
Official Title
Comparison of Skin Prick Testing, Extract-specific IgE Antibody Testing and Component Resolved Diagnosis in Diagnosing of Legume Allergy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or younger
- Signed informed consent to participate in the study
- History of an immediate allergic reaction within 2 hours after eating peas, lentils, chickpeas, or green beans, with skin, gastrointestinal, respiratory, or cardiovascular symptoms
- Positive specific IgE test against ALEX and/or positive skin prick test with the legume
- Positive oral food challenge test with any of the studied legumes
You will not qualify if you...
- Refusal to undergo the oral food challenge
- History of severe systemic allergic reaction to the legume (Ring-Messmer grade 3 or higher)
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Pilsen
Pilsen, Czech Republic, Czechia, 30100
Actively Recruiting
Research Team
M
Martin Liska, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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