Actively Recruiting
Comparison Study of EAP and Disease-Specific Chemotherapy Regimens in Hematopoietic Stem Cell Mobilization for Lymphoma
Led by The Affiliated People's Hospital of Ningbo University · Updated on 2025-12-04
99
Participants Needed
17
Research Sites
104 weeks
Total Duration
On this page
Sponsors
T
The Affiliated People's Hospital of Ningbo University
Lead Sponsor
F
First Affiliated Hospital of Zhejiang University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study utilizes a prospective, multicenter, randomized two-arm design to evaluate the efficacy and safety of the etoposide, cytarabine, and pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) combination therapy (EAP regimen) in mobilizing hematopoietic stem cells in patients with non-Hodgkin's lymphoma (NHL). A total of 99 NHL patients will be enrolled as research subjects and will be randomly allocated in a 2:1 ratio to compare the EAP regimen versus disease-specific chemotherapy mobilization regimen. The primary endpoint is the proportion of patients achieving the ideal collection value after a single collection (CD34+ cells ≥5×10\^6/kg).
CONDITIONS
Official Title
Comparison Study of EAP and Disease-Specific Chemotherapy Regimens in Hematopoietic Stem Cell Mobilization for Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with non-Hodgkin's lymphoma before enrollment
- Indication for autologous stem cell transplantation (ASCT)
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1
- Achieved complete remission after multiple chemotherapy courses
- Life expectancy of at least 3 months
- Able to understand the protocol and sign informed consent
You will not qualify if you...
- Cardiac function class II or higher or cardiac ejection fraction less than 40%
- Serum direct bilirubin more than twice the upper limit of normal
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) more than three times the upper limit of normal
- Serum creatinine clearance rate less than or equal to 50%
- Active infection
- History of prior hematopoietic stem cell mobilization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 17 locations
1
Dongyang People's Hospital
Dongyang, Zhejiang, China
Actively Recruiting
2
The Affiliated Hangzhou First People's Hospital
Hangzhou, Zhejiang, China, 310006
Actively Recruiting
3
The First Affiliated Hospital, College of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
Actively Recruiting
4
Tongde Hospital of Zhejiang Province
Hangzhou, Zhejiang, China
Actively Recruiting
5
Huzhou central hospital
Huzhou, Zhejiang, China
Actively Recruiting
6
The First Hospital of Jiaxing
Jiaxing, Zhejiang, China
Actively Recruiting
7
Jinhua Municipal Central Hospital
Jinhua, Zhejiang, China
Actively Recruiting
8
Jinhua People's Hospital
Jinhua, Zhejiang, China
Actively Recruiting
9
Lishui Central Hospital
Lishui, Zhejiang, China
Actively Recruiting
10
Ningbo Medical Center Lihuili Hospital
Ningbo, Zhejiang, China
Actively Recruiting
11
The Affiliated People's Hospital of Ningbo University
Ningbo, Zhejiang, China
Actively Recruiting
12
Shaoxing People's Hospital
Shaoxing, Zhejiang, China
Actively Recruiting
13
Shaoxing Second Hospital
Shaoxing, Zhejiang, China
Actively Recruiting
14
Taizhou Central Hospital
Taizhou, Zhejiang, China
Actively Recruiting
15
Taizhou Hospital of Zhejiang Province
Taizhou, Zhejiang, China
Actively Recruiting
16
The Second Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China
Actively Recruiting
17
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, China
Actively Recruiting
Research Team
P
Peipei Ye
CONTACT
Y
Ying Lu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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