Actively Recruiting
A Comparison Study of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING
Led by AbbVie · Updated on 2026-02-17
678
Participants Needed
53
Research Sites
212 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will compare the retention rates for UPA vs. TNFi treatment in adult participants with moderate to severe active RA per local label and according to local standard of care This is a mono-country, prospective, multi-center observational study in patients with moderate to severe active RA receiving UPA or TNFi therapy. Around 678 participants will be enrolled in approximately 80 sites in Germany. Study recruitment will last approximately 24 months, and the study participation time will be up to 24 months, for a total study duration of approximately 48 months.
CONDITIONS
Official Title
A Comparison Study of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Current or past diagnosis of moderate to severe active rheumatoid arthritis as confirmed by a physician
- Treatment decision with Upadacitinib (UPA) or tumor necrosis factor inhibitor (TNFi) made by a physician before joining the study
- UPA or TNFi prescribed according to approved labels and local regulations
You will not qualify if you...
- Participation in a clinical trial with an investigational drug within 30 days or 5 half-lives before baseline (whichever is longer)
- Prior treatment with Upadacitinib
- Prior treatment with the same tumor necrosis factor inhibitor as currently prescribed for this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 53 locations
1
Gemeinschaftspraxis Innere Medizin/Rheumatologie /ID# 278584
Freiburg im Breisgau, Baden-Wurttemberg, Germany, 79098
Actively Recruiting
2
Rheumapraxis Heidelberg /ID# 276475
Heidelberg, Baden-Wurttemberg, Germany, 69120
Actively Recruiting
3
Rheumapraxis Haas Tübingen /ID# 275536
Tübingen, Baden-Wurttemberg, Germany, 72072
Actively Recruiting
4
Rheumapraxis Ulm Dr. med. Nadia Rinaldi /ID# 276293
Ulm, Baden-Wurttemberg, Germany, 89073
Actively Recruiting
5
Dr. Med. Thomas Marycz /ID# 274646
Amberg, Bavaria, Germany, 92224
Actively Recruiting
6
Rheumapraxis Am Webereck /ID# 274412
Augsburg, Bavaria, Germany, 86157
Actively Recruiting
7
Dr. Harmuth /ID# 273401
Marktredwitz, Bavaria, Germany, 95615
Actively Recruiting
8
Praxiszentrum Dr. Med. Klaus Krüger Dres. Günther Kellerer Und Paul Kellerer /ID# 276138
Munich, Bavaria, Germany, 81541
Actively Recruiting
9
Klinische Forschung Im Medizinischen Versorgungalltag Gbr /ID# 274587
Planegg, Bavaria, Germany, 82152
Actively Recruiting
10
Private Practice - Dr. Dirk Wernicke /ID# 276820
Hohen Neuendorf, Brandenburg, Germany, 16540
Actively Recruiting
11
Praxis K. Pagel /ID# 279121
Hoppegarten, Brandenburg, Germany, 15366
Actively Recruiting
12
Rheumahaus Studien GbR /ID# 275917
Potsdam, Brandenburg, Germany, 14467
Actively Recruiting
13
Rheumatologisch Immunologisch /ID# 275830
Templin, Brandenburg, Germany, 17268
Actively Recruiting
14
Rheumatism Center Mittelhessen /ID# 274641
Bad Endenbach, Hesse, Germany, 35080
Actively Recruiting
15
Deutsches Endokrinologisches Versorgungszentrum DEVZ - MVZ GdR /ID# 274291
Frankfurt am Main, Hesse, Germany, 60329
Actively Recruiting
16
Rheumapraxis Hannover-List /ID# 273735
Hanover, Lower Saxony, Germany, 30161
Actively Recruiting
17
Praxis. F. Bigdeli-Wilshusen /ID# 273455
Hanover, Lower Saxony, Germany, 30173
Actively Recruiting
18
Rheumatologie Kassel /ID# 275916
Kassel, Lower Saxony, Germany, 34125
Actively Recruiting
19
Rheumapraxis An Der Hase /ID# 276949
Osnabrück, Lower Saxony, Germany, 49074
Actively Recruiting
20
Fachpraxis für Rheumatologie und Osteologie /ID# 275359
Weyhe, Lower Saxony, Germany, 28844
Actively Recruiting
21
Private Practice - Dr. Thilo Klopsch - Stargarder Strasse /ID# 276367
Neubrandenburg, Mecklenburg-Vorpommern, Germany, 17033
Actively Recruiting
22
Rheumazentrum Ruhrgebiet /ID# 275518
Herne, North Rhine-Westphalia, Germany, 44649
Actively Recruiting
23
St.Elisabeth Hospital Meerbusch /ID# 275030
Meerbusch, North Rhine-Westphalia, Germany, 40668
Actively Recruiting
24
Rheumazentrum Ratingen /ID# 275707
Ratingen, North Rhine-Westphalia, Germany, 40882
Actively Recruiting
25
Praxis Dr. med. Florian Beyer /ID# 274293
Kaiserslautern, Rhineland-Palatinate, Germany, 67657
Actively Recruiting
26
Rheumapraxis am Schlossberg /ID# 272728
Homburg, Saarland, Germany, 66424
Actively Recruiting
27
Dr. Murawski /ID# 272724
Neunkirchen, Saarland, Germany, 66538
Actively Recruiting
28
Knappschaftsklinikum Saar /ID# 279852
Püttlingen, Saarland, Germany, 66346
Actively Recruiting
29
Rheumapraxis Dr. Prothmann /ID# 279851
Püttlingen, Saarland, Germany, 66346
Actively Recruiting
30
Medizinischen Versorgungszentrums Agilomed /ID# 274887
Chemnitz, Saxony, Germany, 09130
Actively Recruiting
31
Dr. Mueller /ID# 273081
Freiberg, Saxony, Germany, 09599
Actively Recruiting
32
Private Practice - Dr. Frank Hamann, Dr. Andreas Teich & Dr. Konrad Boche /ID# 275358
Leipzig, Saxony, Germany, 04109
Actively Recruiting
33
Private Practice - Dr. Ilka Schwarze /ID# 276981
Leipzig, Saxony, Germany, 04129
Actively Recruiting
34
Private Practice - Dr. Christine Baumann /ID# 275095
Plauen, Saxony, Germany, 08523
Actively Recruiting
35
Praxis H. Fricke-Wagner /ID# 274467
Zwickau, Saxony, Germany, 08056
Actively Recruiting
36
Rheumapraxis Dr. Liebhaber /ID# 274888
Halle, Saxony-Anhalt, Germany, 06128
Actively Recruiting
37
Rheumatologische Facharztpraxis /ID# 272866
Magdeburg, Saxony-Anhalt, Germany, 39104
Actively Recruiting
38
Private Practice - Dr. Jochen Walter /ID# 280069
Rendsburg, Schleswig-Holstein, Germany, 24768
Actively Recruiting
39
Private Practice - Dr. Thomas Kupka /ID# 273631
Altenburg, Thuringia, Germany, 04600
Actively Recruiting
40
Rheumapraxis Weimar /ID# 272740
Weimar, Thuringia, Germany, 99427
Actively Recruiting
41
MVZ Weserbergland /ID# 276009
Bad Pyrmont, Germany, 31812
Completed
42
Private Practice - Dr. Silke Zinke /ID# 276366
Berlin, Germany, 13055
Actively Recruiting
43
MVZ Herzogin Elisabeth Hospital /ID# 272725
Braunschweig, Germany, 38114
Actively Recruiting
44
Private Practice - Dr. Sebastian Schuh /ID# 272731
Coburg, Germany, 96450
Actively Recruiting
45
Rheumapraxis Düren /ID# 272726
Düren, Germany, 52355
Actively Recruiting
46
Praxis Dilltal /ID# 272727
Ehringshausen, Germany, 35630
Actively Recruiting
47
Private Practice - Dr. Daniel Bestler /ID# 272741
Erfurt, Germany, 99096
Actively Recruiting
48
Praxis Fiene /ID# 279410
Greifswald, Germany, 17493
Actively Recruiting
49
Private Practice - Dr. Hauke E. Heintz /ID# 278081
Hamburg, Germany, 22391
Actively Recruiting
50
Rheumatologische Facharztpraxis /ID# 272743
Naumburg, Germany, 06618
Actively Recruiting
51
Praxis F. Schattenberg /ID# 280322
Waren, Germany, 17192
Actively Recruiting
52
Cellitinnen-Krankenhaus St. Josef /ID# 275926
Wuppertal, Germany, 42105
Actively Recruiting
53
Praxis Barmen /ID# 277514
Wuppertal, Germany, 42285
Actively Recruiting
Research Team
M
Medical Information Germany
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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