Actively Recruiting

Phase 2
Age: 18Years - 40Years
All Genders
ID07208799

Comparison of Effectiveness of Submucosal Dexamethasone and Methylprednisolone in Management of Postoperative Sequelae in Mandibular Parasymphysis Fractures

Led by Nishtar Medical University · Updated on 2026-04-06

72

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating the effects of two corticosteroids, dexamethasone and methylprednisolone, on reducing postoperative pain, swelling, and limited mouth opening (trismus) in patients with isolated mandibular parasymphysis fractures. This clinical trial addresses the current uncertainty about which steroid is more effective for managing these postoperative complications. The study aims to provide clear evidence to guide clinicians in choosing the best steroid treatment to improve patient recovery after surgery. The trial compares two groups: one receiving a single submucosal dose of dexamethasone (8 mg) and the other receiving a single submucosal dose of methylprednisolone (40 mg). Both drugs are administered at the surgical site 30 minutes before the incision during open reduction and internal fixation surgery. The study uses a double-blind, randomized design to fairly assess the outcomes of both treatments. Participants will be monitored for facial swelling and pain intensity at baseline, 24 hours, and 72 hours after surgery. Blood samples will be taken to measure serum C-reactive protein, an objective marker of inflammation, at the same time points. Researchers will also track the use of additional pain medication and any side effects. This thorough assessment combining clinical signs and lab tests will help determine which steroid provides better postoperative control of symptoms. The study will continue until late 2026, ensuring comprehensive follow-up.

CONDITIONS

Brief Title

Comparison of Submucosal Dexamethasone and Methylprednisolone in Postoperative Sequelae of Parasymphsis Fractures

Who Can Participate

Age: 18Years - 40Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients aged 18 to 40 years
  • Both genders
  • Fracture less than a week old
  • Isolated mandibular parasymphysis fractures
Not Eligible

You will not qualify if you...

  • Immunocompromised patients
  • Patients with acute pain from pulpitis, abscesses, or other infections
  • Patients with hypersensitivity to steroids
  • Patients taking or requiring antibiotics or anti-inflammatory drugs before surgery
  • Patients with systemic steroid use in the past 15 days
  • Patients with chronic pain problems or mental disorders
  • Patients with comminuted fractures
  • Pregnant or lactating women
  • Smokers of at least 10 cigarettes per day for 2 years

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Surgery day

Participants receive a single submucosal injection of either dexamethasone or methylprednisolone 30 minutes before surgery to reduce postoperative pain and swelling.

1 visit (in-person)

Post-operative Follow-up

Duration - 72 hours after surgery

Participants are monitored for postoperative pain, facial swelling, and inflammation through clinical assessments and blood tests.

2 visits (in-person) at 24 and 72 hours post-surgery

Trial Site Locations

Total: 1 location

1

Nishtar Institute of Dentistry Multan

Multan, Punjab Province, Pakistan, 60000

Actively Recruiting

Loading map...

Research Team

A

Ammar ali khalid, Bachelor of dental surgery

D

Dr amjad Bari, M.D.S (OMFS)

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

Similar Trials

Acute Effects of Transcutaneous Electrical Nerve Stimulation...

Pain Management

Actively Recruiting

1 location

Factors Influencing Analgesic Consumption in the Early Posto...

Postoperative Pain

Actively Recruiting

1 location

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Published Research Related To This Trial

C-reactive protein estimation: a quantitative analysis for three nonsteroidal anti-inflammatory drugs: a randomized control trial.

Gaurav Salgia, Deepak G Kulkarni, Lakshmi Shetty

https://pubmed.ncbi.nlm.nih.gov/25961614

Do the Benefits of Systemic Corticosteroids Outweigh Adverse Effects During Maxillofacial Trauma Surgery? A Systematic Review and Meta-Analysis.

Ashutosh Kumar Singh, Safal Dhungel, Kushal Bhattarai...

https://pubmed.ncbi.nlm.nih.gov/33745861

Evaluation of effect of submucosal administration of depomedrol in management of postoperative sequelae in mandibular fractures: A randomized clinical trial study.

Janani Kandamani, Sudarssan Subramaniam Gouthaman, Divya Sanjeevi Ramakrishnan...

https://pubmed.ncbi.nlm.nih.gov/35911819

A randomized clinical trial of the effects of submucosal dexamethasone after surgery for mandibular fractures.

Ashok Dongol, Mehul Rajesh Jaisani, Leeza Pradhan...

https://pubmed.ncbi.nlm.nih.gov/25843816

Submucosal injection of dexamethasone and methylprednisolone for the control of postoperative sequelae after third molar surgery: randomized controlled trial.

A Chugh, S Singh, Y Mittal...

https://pubmed.ncbi.nlm.nih.gov/28811076