Actively Recruiting
Comparison of Surgical Management of Early Pregnancy Loss by Suction Curettage Versus Hysteroscopy in Patients Undergoing In-vitro Fertilization (IVF)
Led by Assaf-Harofeh Medical Center · Updated on 2026-01-27
50
Participants Needed
2
Research Sites
105 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Early pregnancy loss occurs in \~15% of pregnancies. The treatment options include surgical uterine evacuation by suction curettage, medical management with misoprostol, or conservative management without interventions. The advantages of surgical management include quick resolution of the pregnancy and avoidance of heavy vaginal bleeding, while the disadvantages include retained products of conception and intrauterine adhesion formation which could affect future fertility. With the aim of reducing the complications of suction curettage, uterine evacuation using operative hysteroscopy has been suggested. In a previous study, the investigators compared suction curettage with operative hysteroscopy for the surgical management of early pregnancy loss up to 10 weeks of gestation. The results showed significantly reduced adhesions rate (4.2% in the hysteroscopy group vs. 45.2% in the suction group, p \< 0.01), although the operative time was significantly longer for the hysteroscopy. In this follow-up study, the investigators will compare the outcomes of hysteroscopy and suction curettage in a select group of patients with early pregnancy loss following conception by in-vitro fertilization. These patients are at risk for adhesions and therefore candidates for the hysteroscopic intervention. The study will include 50 patients randomized to 2 intervention arms - hysteroscopy using a tissue removal device versus the standard suction curettage. Post-operative adhesions will be assessed by office hysteroscopy after 6-8 weeks.
CONDITIONS
Official Title
Comparison of Surgical Management of Early Pregnancy Loss by Suction Curettage Versus Hysteroscopy in Patients Undergoing In-vitro Fertilization (IVF)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of early pregnancy loss up to 10 weeks' gestation based on last menstrual period or ultrasound
- Pregnancy conceived through assisted reproductive techniques (in vitro fertilization, IVF)
- Ability to provide informed consent and proficiency in reading and writing Hebrew
You will not qualify if you...
- Heavy vaginal bleeding or diagnosis of incomplete abortion
- Signs of infection or suspicion of septic abortion
- Known uterine anomalies including septate, bicornuate, unicornuate, or didelphys uterus
- Prior medical or surgical treatment during the current pregnancy
- History of intrauterine adhesions
- History of 3 or more prior miscarriages
- History of 3 or more prior cesarean sections
- History of myomectomy via abdominal or hysteroscopic approach
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Shamir Medical Center
Be’er Ya‘aqov, Israel, 70200
Actively Recruiting
2
Sheba Medical Center, Tel Hashomer
Ramat Gan, Israel, 52621
Active, Not Recruiting
Research Team
N
Noam Smorgick, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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