Actively Recruiting
Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery
Led by Istanbul University - Cerrahpasa · Updated on 2026-03-25
70
Participants Needed
2
Research Sites
15 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to investigate the effect of target-controlled infusion using the Eleveld pharmacokinetic model compared with manually controlled total intravenous anesthesia on the incidence of postoperative delirium in patients undergoing supratentorial surgery. Propofol and remifentanil are administered using either target-controlled or manual infusion techniques according to the study protocol. Secondary objectives include comparisons of intraoperative anesthetic consumption, hemodynamic responses, recovery profiles, postoperative pain, and postoperative nausea and vomiting between the two anesthesia strategies. The study seeks to evaluate whether target-controlled infusion provides improved anesthetic management and postoperative outcomes compared with manual total intravenous anesthesia.
CONDITIONS
Official Title
Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 to 60 years
- Scheduled for elective supratentorial surgery under general anesthesia
- American Society of Anesthesiologists (ASA) physical status I or II
- Planned total intravenous anesthesia with propofol and remifentanil
- Ability to provide written informed consent
You will not qualify if you...
- Refusal or inability to provide written informed consent
- American Society of Anesthesiologists (ASA) physical status III or higher
- Pregnancy
- Emergency surgery
- Presence of brain herniation
- Anticipated or documented difficult airway
- Inability to communicate effectively (e.g., non-Turkish speaking or hearing impairment)
- Preoperative risk factors for delirium, including substance abuse, use of neuropsychiatric medications, preoperative hemoglobin level < 8 g/dL, malnutrition, or electrolyte or thyroid hormone abnormalities
- Intraoperative deviation from the study protocol, including changes in surgical or anesthetic technique or occurrence of major intraoperative complications
- Contraindications to propofol or remifentanil
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine
Istanbul, Bakırköy, Turkey (Türkiye), 34153
Not Yet Recruiting
2
Cerrahpaşa Tıp Fakültesi Murat Dilmener Hastanesi
Istanbul, Istanbul, Turkey (Türkiye), 34153
Actively Recruiting
Research Team
A
Ali Okuyan, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here