Comparing Two Lymphadenectomy Methods Using V-NOTES Surgery in Women With Early Stage Endometrial Cancer

What this Trial Is About

Researchers are evaluating two types of lymphadenectomytransperitoneal and transvaginal paracervicalduring the lymphadenectomy phase of endometrial cancer staging surgery using V-NOTES, a new and advanced surgical approach. This randomized, prospective, controlled study aims to optimize the V-NOTES technique for staging early-stage endometrial cancer by comparing surgical and functional outcomes between the two methods. Patients diagnosed with endometrial cancer through biopsy and imaging are enrolled and randomly assigned to one of the two lymphadenectomy groups. In the transvaginal paracervical lymphadenectomy group, patients undergo V-NOTES surgery beginning with methylene blue dye injection around the cervix, followed by sentinel lymph node mapping, hysterectomy, and removal of ovaries and fallopian tubes. The transperitoneal lymphadenectomy group receives V-NOTES surgery starting with methylene blue injection, anterior and posterior colpotomies, placement of the V-NOTES device, hysterectomy, and then lymph node removal through peritoneal dissection. Both groups receive similar surgical procedures with differences in lymphadenectomy approach. Participants will be assessed during surgery and hospitalization for operation duration, bleeding, lymph node removal, and complications. Follow-up evaluations include postoperative pain and sexual function at 3 and 6 months. Tumor pathology and other surgical outcomes are monitored up to the study completion. The study duration covers recruitment from March to December 2025 with ongoing follow-up through early 2026. Data will be collected on surgical safety, effectiveness of lymph node mapping, and recovery measures.

Comparison of Transvaginal Paracervical and Transperitoneal Approaches in Lymphadenectomy During v-NOTES Surgery for Patients Diagnosed With Endometrial Cancer