NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors.
George D Demetri, Margaret von Mehren, Cristina R Antonescu...
https://pubmed.ncbi.nlm.nih.gov/20457867/Actively Recruiting
Led by Fujian Medical University · Updated on 2025-04-08
250
Participants Needed
1
Research Sites
N/A
Total Duration
This research aims to compare the safety and effectiveness of laparoscopic surgery for gastrointestinal stromal tumors GIST located in different parts of the stomach. Participants are divided into groups based on whether their tumor is in a favorable or unfavorable site. The study focuses on evaluating the rates of complications and mortality after surgery, as well as the 3-year disease-free survival rate. The treatment under study is laparoscopic resection of GIST performed under general anesthesia. Participants will be grouped based on tumor location into favorable or unfavorable site groups, both receiving the standard surgical therapy. The main comparison is between these two groups regarding surgical outcomes and long-term survival. The study monitors patients for at least three years after surgery. Participants will undergo laparoscopic surgery and then be closely followed for various outcomes including postoperative complications, recovery milestones like first ambulation and diet tolerance, and survival rates over three years. Researchers will collect data on tumor recurrence, surgical margins, hospital stay duration, and changes in blood markers before and after surgery. Safety and recovery are monitored for up to 30 days post-surgery, with long-term follow-up extending to 36 months.
CONDITIONS
Comparison of Tumor Efficacy Safety in Laparoscopic Resection of Gastrointestinal Stromal Tumors Between Favorable and Unfavorable Site
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Fujian Medical University
Lead Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 30 days
Participants undergo laparoscopic resection of gastrointestinal stromal tumors under general anesthesia followed by immediate post-operative monitoring.
Multiple visits during hospital stay and early recovery
Duration - Up to 3 years
Participants are monitored for disease-free survival, recurrence, and overall survival following surgery.
Periodic visits over 36 months
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Have more questions? Get in touch with our team for quick support
George D Demetri, Margaret von Mehren, Cristina R Antonescu...
https://pubmed.ncbi.nlm.nih.gov/20457867/Michitaka Honda, Naoki Hiki, Souya Nunobe...
https://pubmed.ncbi.nlm.nih.gov/24566748/Jianxian Lin, Changming Huang, Chaohui Zheng...
https://pubmed.ncbi.nlm.nih.gov/24853837/Sabha Ganai, Vivek N Prachand, Mitchell C Posner...
https://pubmed.ncbi.nlm.nih.gov/23225195/Markku Miettinen, Mourad Majidi, Jerzy Lasota
https://pubmed.ncbi.nlm.nih.gov/12528772/Ye-Xin Koh, Aik-Yong Chok, Hui-Li Zheng...
https://pubmed.ncbi.nlm.nih.gov/23793362/Luigi Masoni, Ivan Gentili, Riccardo Maglio...
https://pubmed.ncbi.nlm.nih.gov/24879133/Chang-Ming Huang, Qing-Feng Chen, Jian-Xian Lin...
https://pubmed.ncbi.nlm.nih.gov/28383420/Laleh G Melstrom, Joseph D Phillips, David J Bentrem...
https://pubmed.ncbi.nlm.nih.gov/21552096/S Q Nguyen, C M Divino, J-L Wang...
https://pubmed.ncbi.nlm.nih.gov/16502196/Fujian Medical University
Lead Sponsor