Actively Recruiting
Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients
Led by University Hospital, Angers · Updated on 2026-03-17
40
Participants Needed
1
Research Sites
115 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Huntington's disease (HD) is a rare, hereditary neurodegenerative disorder. It generally manifests itself between the ages of 40 and 50, and results in motor impairment (choreic movements, balance disorders, gait disorders, etc.), cognitive impairment (executive functions, attention, etc.) and behavioral impairment (apathy, depression, irritability, etc.). To date, there is no curative treatment for HD, and drug therapies have little effect on symptomatology, particularly motor symptoms. Physical activity and cognitive stimulation appear to be promising tools in the fight against the progression of various symptoms in certain progressive neurological conditions, including HD. In addition, the use of exergame as an interface is becoming increasingly widespread and offers encouraging prospects in the management of certain neurodegenerative diseases (Parkinson's disease, multiple sclerosis, spinocerebellar ataxia type 3). The aim of our project is to carry out a preliminary evaluation of the clinical benefit of a management program combining physical activity and cognitive stimulation, compared with a sequential management program.
CONDITIONS
Official Title
Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults at inclusion
- Confirmed diagnosis of Huntington's disease by genetic analysis
- Patient with stage 1-2 Huntington's disease with motor UHDRS score ≥ 5 and CFT between 6 and 13
- Patient has provided written informed consent or third-party consent
- Affiliated with or beneficiary of a social security scheme
You will not qualify if you...
- Poor understanding of the French language
- Participation in interventional research modifying management
- History likely to interfere with cognition such as stroke, traumatic brain injury, active epilepsy, learning disorders, alcohol dependence syndrome, drug use, or psychiatric disorders
- Severe cognitive deficit (MMSE score <16)
- Clinically significant pathological condition interfering with safety or evaluation
- Pregnant or breastfeeding women
- Persons deprived of liberty by administrative or judicial decision
- Persons under compulsory psychiatric care
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Angers University hospital
Angers, France
Actively Recruiting
Research Team
C
Clarisse SCHERER GAGOU, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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