Actively Recruiting
Comparison of Two Different Sperm Processing Methods and Their Effects on Sperm DNA Fragmentation and Embryo Development
Led by Richard Kordus, PhD, HCLD (ABB) · Updated on 2025-09-17
50
Participants Needed
1
Research Sites
68 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if the LensHooke CA0 device lowers DNA fragmentation in sperm samples compared to a gradient/swim-up technique. The main questions it aims to answer are: 1. Does the LensHooke® CA0 device reduce DNA fragmentation compared to the gradient/swim-up technique? 2. Does the LensHooke® CA0 device improve concentration, motility, and morphology compared to the gradient/swim-up technique? 3. Is sibling embryo fertilization and development the same? 4. Are pregnancy rates different between the 2 groups? 1 semen sample will be split between the 2 treatment techniques. Half of the partner's egg cohort will be injected via intra-cytoplasmic sperm using sperm processed by one technique and the other half of the cohort will be injected by the sperm processed by the other technique. Both methods will look at DNA fragmentation, concentration, motility, and morphology of the sperm. Both methods will be compared in the resulting embryos looking at fertilization, embryo development and pregnancy rates.
CONDITIONS
Official Title
Comparison of Two Different Sperm Processing Methods and Their Effects on Sperm DNA Fragmentation and Embryo Development
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Samples with at least 15 million sperm per milliliter concentration
- Female partner aged between 18 and 34 years
- Minimum of 4 fertilized eggs in the gradient/swim-up group and 4 fertilized eggs in the LensHooke preparation group for each patient
You will not qualify if you...
- Samples with less than 15 million sperm per milliliter concentration
- Female partner older than 35 years
- Female partner with recurrent pregnancy loss
- Female partner with diminished ovarian reserve
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Prisma Health-Upstate Fertility Center of the Caroliinas
Greenville, South Carolina, United States, 29605
Actively Recruiting
Research Team
R
Richard J Kordus, PhD
CONTACT
P
Patti Parker
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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