Actively Recruiting
Comparison of Two Dosing Regimens of Intravenous Ketorolac for Post-Cesarean Pain Control: A Randomized Controlled Trial
Led by Cairo University · Updated on 2026-01-13
126
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare the pain-relieving effects of two intravenous ketorolac dosing schedules as part of a combined pain management plan that includes local wound anesthesia after planned cesarean delivery. The study focuses on women aged 18 to 35 undergoing elective cesarean sections with spinal anesthesia to better understand how different ketorolac doses control postoperative pain. Participants will receive spinal anesthesia with bupivacaine and fentanyl, followed by a single dose of dexamethasone together with the first intravenous ketorolac dose after delivery. They will be randomly assigned to receive either 30 mg or 15 mg of intravenous ketorolac every 8 hours postoperatively. The surgical wound's subcutaneous layer will be numbed with bupivacaine, and additional pain medication nalbuphine will be given as needed based on pain scores. During the study, pain levels will be regularly measured using a numeric rating scale at rest and during movement at various times up to 24 hours after surgery. Researchers will track total nalbuphine use, time to first additional pain medication, quality of recovery scores, and patient satisfaction. The study uses a randomized and quadruple-masked design, with careful monitoring of participants’ responses to the different ketorolac doses over the first day following surgery.
CONDITIONS
Brief Title
Comparison of Two Dosing Regimens of Intravenous Ketorolac for Post-Cesarean Pain Control
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Full-term, singleton pregnant women
- Aged 18 to 35 years
- Scheduled for elective cesarean delivery under spinal anesthesia
You will not qualify if you...
- American Society of Anesthesiologists (ASA) physical class III or higher
- Multiple gestation pregnancy
- History of allergy to any study drugs
- Renal impairment
- Gastrointestinal bleeding or ulceration
- Inflammatory bowel disease
- Chronic pain or regular opioid use
- Inability to understand the numeric pain scale or ObsQoR-11 score
- Need for conversion to general anesthesia after spinal anesthesia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 24 hours postoperatively
Participants receive intravenous ketorolac for post-cesarean pain control every 8 hours after delivery along with a single dose of dexamethasone and local anesthesia infiltration.
1 baseline visit and multiple assessments during the first 24 hours postoperatively
Trial Site Locations
Total: 1 location
1
Kasr Alainy Hospital
Cairo, Egypt, 11562
Actively Recruiting
Research Team
M
Maha Mostafa, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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