Actively Recruiting
Comparison of Two Oxygenation Targets With Two Different Oximeters - Impact on Oxygen Flow Rates and Oxygenation
Led by Laval University · Updated on 2025-09-04
40
Participants Needed
1
Research Sites
236 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators recently evaluated 4 different oximeters among the most commonly used with arterial catheter in place and compared SpO2 with SaO2 obtained on arterial gas. Correlations between SaO2 and SpO2 were poor for all oximeters, as previously known, and SpO2-SaO2 bias were different between oximeters. Some oximeters (Masimo, Nellcor) had lower biases but they detected less well hypoxemia. Some oximeters underestimated SaO2 (Nonin) but detected very well hypoxemia, and some overestimated SaO2 (Philips). The investigators concluded that oximeters provide different informations to clinicians, and oxygenation targets should take into account for these differences. The assumption is that the SpO2 target AND oximeter used will both have an impact on oxygen flows and that these effects will add up. With a high SpO2 target, oxygen flows will be significantly greater and with the Nonin oximeter, the required flows will be greater than with the Philips oximeter. NB: the results obtained were in a population with light skin pigmentation (96% of the patients were Fitzpatrick 1-2, reflecting the local hospitalized population).
CONDITIONS
Official Title
Comparison of Two Oxygenation Targets With Two Different Oximeters - Impact on Oxygen Flow Rates and Oxygenation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Admitted to postoperative cardiac surgery intensive care unit
- Presence of an arterial catheter
- Receiving conventional oxygen therapy at moderate flow (up to 5 L/min) with SpO2 between 88% and 100% using usual oximeter and nasal cannula
- For extubated patients, SpO2 below 92% on ambient air
- For intubated patients, FiO2 less than or equal to 0.60 with SpO2 between 88% and 100% using usual oximeter
- SpO2 below 92% with FiO2 0.21
You will not qualify if you...
- No SpO2 signal with the oximeter in use
- Use of false nails or nail polish
- Methemoglobinemia greater than 0.015 on last arterial gas
- Patient in isolation due to multi-resistant bacteria, C-Difficile, SARS-CoV-2 (for extubated patients)
- Expected to require other respiratory support within one hour of inclusion (non-invasive ventilation or nasal high flow oxygen)
- Planned extubation within one hour of inclusion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Institut Universitaire de Cardiologie et de Pneumologie de Québec
Québec, Quebec, Canada, G1V4G5
Actively Recruiting
Research Team
F
Francois Lellouche
CONTACT
P
Pierre Alexandre Bouchard
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here