Actively Recruiting
A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients
Led by University of Greifswald · Updated on 2023-10-12
396
Participants Needed
6
Research Sites
230 weeks
Total Duration
On this page
Sponsors
U
University of Greifswald
Lead Sponsor
G
German Research Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to compare the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) conducted over 16 weeks (acute and continuation treatment) with Behavioral Activation (BA; same dose and duration) in persistently depressed treatment-resistant inpatients regarding efficacy, moderators and mediators of change.
CONDITIONS
Official Title
A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Primary DSM-5 diagnosis of persistent depressive disorder (PDD)
- Hamilton Depression Rating Scale (HDRS-24) score of 20 or higher
- Treatment-resistant depression defined by at least three antidepressant treatments or one psychotherapy of 25+ sessions in the current episode
- Sufficient knowledge of the German language
- Written informed consent provided
You will not qualify if you...
- Diagnosis of bipolar I or II disorder
- Active substance use disorder with less than 6 months of abstinence
- Schizophrenia spectrum or other psychotic disorders
- Antisocial personality disorder
- Acute suicidality
- Previous CBASP or BA treatment within the last year
- Inability to tolerate CBASP or BA due to brain disorders or severe cognitive deficits
- Inability to participate in dayclinic or outpatient continuation treatment
AI-Screening
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Trial Site Locations
Total: 6 locations
1
Charité, University Medicine Berlin
Berlin, Germany, 10117
Actively Recruiting
2
Medizinische Hochschule Hannover
Hanover, Germany, 30625
Not Yet Recruiting
3
Universität zu Lübeck
Lübeck, Germany, 23562
Actively Recruiting
4
Universitätsklinikum Marburg
Marburg, Germany, 35039
Actively Recruiting
5
Klinikum der Universität München
München, Germany, 80336
Actively Recruiting
6
Universitätsklinikum Tübingen
Tübingen, Germany, 72076
Actively Recruiting
Research Team
E
Eva-Lotta Brakemeier, Prof. Dr.
CONTACT
J
Johannes Zimmermann, Prof. Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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