Actively Recruiting
Comparison of Two SpO2 Targets With Two Different Oximeters Impact on FiO2 During Nasal High Flow Oxygen Therapy
Led by Laval University · Updated on 2026-03-09
30
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how different oxygen saturation (SpO2) targets and types of oximeters affect the amount of oxygen (FiO2) given to patients receiving high-flow nasal oxygen therapy. The study aims to understand how factors like the type of oximeter and the oxygenation goal influence oxygen delivery, which is important for optimizing treatment in patients with acute respiratory failure. The study compares two different oximeters, Nonin and Philips, each tested with two SpO2 targets: 90% and 94%. Participants will undergo four randomized 10-minute periods using each combination of oximeter and SpO2 target. During these periods, oxygen flow will be manually adjusted to reach the assigned SpO2 target. At the end of each period, arterial blood gas samples will be collected to assess oxygen levels. Participants will be monitored closely during the study with continuous oxygen therapy and arterial catheter measurements. Researchers will measure the mean FiO2 during the final two minutes of each period, differences between SpO2 and arterial oxygen saturation, and criteria related to weaning, intensive care transfer, and intubation. The study ensures careful observation of oxygen delivery and response to therapy over these short treatment intervals.
CONDITIONS
Brief Title
Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Admitted to an intensive care unit
- Presence of an arterial catheter
- Currently receiving high-flow nasal oxygen therapy with SpO2 between 88% and 100% and FiO2 between 40% and 80% using the usual oximeter
You will not qualify if you...
- No SpO2 signal with the oximeter in use
- Presence of false nails or nail polish
- Methemoglobinemia greater than 0.015 on the last available arterial gas
- Patient in isolation due to multi-resistant bacteria, C-Difficile, SARS-CoV-2, or similar
- Expected to require another respiratory support (NIV or mechanical ventilation) within two hours of inclusion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 1 hour
Participants receive four 10-minute periods of oxygen therapy using different oximeters and SpO2 targets in randomized order. At the end of each period, arterial blood is collected through an arterial catheter.
1 in-person visit with 4 consecutive treatment periods
Trial Site Locations
Total: 1 location
1
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
Québec, Quebec, Canada, G1V4G5
Actively Recruiting
Research Team
F
Francois Lellouche Principal Investigator
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
4
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