Stapled Antimesenteric Functional End-to-end Anastomosis (Kono-S) Versus Stapled Antimesenteric Isoperistaltic Side-to-side Anastomosis for the Postoperative Recurrence of Crohn's Disease: a Randomized Control Trial Study

What this Trial Is About

Researchers are comparing two types of stapled antimesenteric anastomosis techniques used after bowel resection in patients with Crohn's disease to see which is better at reducing postoperative recurrence. Crohn's disease can often return after surgery, and while the stapled anti-mesenteric functional end-to-end anastomosis (Kono-S) has been found safe, its benefit over the conventional stapled antimesenteric isoperistaltic side-to-side anastomosis is unknown. This randomized control trial aims to explore the difference in recurrence rates following these two surgical methods. Participants will be randomly assigned to receive either the stapled Kono-S anastomosis or the stapled antimesenteric isoperistaltic side-to-side anastomosis after their bowel resection. Both are surgical procedures performed during the operation to reconnect the bowel. The study will monitor the patients over time to compare the outcomes of these two anastomosis techniques. Throughout the study, researchers will assess the endoscopic recurrence rate of Crohn's disease one year after surgery, which is the primary outcome measure. Secondary outcomes include clinical and surgical recurrence rates at one and five years post-surgery, as well as quality of life assessments using the inflammatory bowel disease questionnaire (IBDQ) and Short Form 12 surveys. The study is double-blinded and randomized, with participants aged 16 to 60 years, and involvement may last several years to capture these outcomes.

Comparison of Two Stapled Antimesenteric Anastomosis for CD: a Randomized Control Trial Study