Actively Recruiting
Comparison of Two Strategies of One-lung Ventilation in Patients Undergoing Carcinological Lung Resection Surgery.
Led by University Hospital, Montpellier · Updated on 2026-03-31
120
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
During thoracic surgery, one-lung ventilation (OLV) is associated with hypoxemia, lung injury, and perioperative respiratory complications. The level of positive-end expiratory pressure (PEEP) to apply during OLV remains controversial. The open-lung approach consists in setting a level of PEEP corresponding to the best lung compliance, using an esophageal catheter to measure the transpulmonary pressure. This approach has been effective in laparoscopic surgeries or acute respiratory distress syndrome, but has never been evaluated in thoracic surgery.
CONDITIONS
Official Title
Comparison of Two Strategies of One-lung Ventilation in Patients Undergoing Carcinological Lung Resection Surgery.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be 18 years of age or older
- Be scheduled for lung cancer resection surgery by video-assisted thoracoscopy or thoracotomy
- Be able to attend all scheduled visits and comply with all trial procedures
You will not qualify if you...
- Lung resection performed for non-cancer reasons (e.g., bullous emphysema reduction, lung abscess)
- History of or planned bilateral pulmonary resection surgery
- Lung resection done under sternotomy
- Non-intubated video-assisted thoracoscopy
- Robotic thoracic surgery
- Contraindications to esophageal catheter (esophageal varices, hepatic cirrhosis Child 65 b, esophageal or gastric surgery, thoracic radiotherapy, latex allergy)
- American Society of Anesthesiologists (ASA) score of 4 or higher
- Severe chronic obstructive pulmonary disease GOLD III or IV (FEV <50%)
- Uncontrolled asthma (FEV <50%)
- Intracardiac shunt
- Hemoglobinopathy affecting oxygen saturation measurement
- Heart failure NYHA class III or IV
- Documented pulmonary hypertension (mean pulmonary arterial pressure >20 mmHg)
- Under legal protection
- Unable to read or write
- Lack of or refusal to give informed consent
- Pregnancy, nursing, or planning pregnancy during the study
- Not affiliated with the French social security system or beneficiary thereof
AI-Screening
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Trial Site Locations
Total: 1 location
1
Département d'Anesthésie et Réanimation Cardiothoracique - CHU Arnaud de Villeneuve
Montpellier, France, 34090
Actively Recruiting
Research Team
H
Hélène Dr DAVID
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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