Actively Recruiting
Comparison of Two Vaginal Progesterone Forms in Frozen Embryo Transfer
Led by Instituto Valenciano de Infertilidade de Lisboa · Updated on 2026-03-10
400
Participants Needed
1
Research Sites
107 weeks
Total Duration
On this page
Sponsors
I
Instituto Valenciano de Infertilidade de Lisboa
Lead Sponsor
G
Gedeon Richter Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to compare two commonly used vaginal progesterone formulations - soft capsules versus pessaries - in women undergoing frozen embryo transfer (FET). The main question it aims to answer is: \- Do soft vaginal progesterone capsules provide similar or better patient satisfaction, convenience, and tolerability compared with vaginal progesterone pessaries during preparation for frozen embryo transfer? Participants undergoing FET who are prescribed vaginal progesterone as part of their endometrial preparation and luteal phase support will use one of the two formulations and complete patient-reported assessments regarding satisfaction, convenience, and tolerability. The study will also measure serum progesterone levels on the day of embryo transfer and evaluate pregnancy outcomes, including clinical pregnancy and live birth rates.
CONDITIONS
Official Title
Comparison of Two Vaginal Progesterone Forms in Frozen Embryo Transfer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to less than 49 years old
- Body Mass Index (BMI) between 18.5 and less than 30 kg/m2
- Planned for single blastocyst stage frozen embryo transfer
- Prescribed vaginal progesterone soft capsules (two 200 mg capsules) or pessaries (one 400 mg pessary) every 12 hours before and after FET
- Undergoing artificial cycle (AC-FET) or natural proliferative phase frozen embryo transfer (NPP-FET)
You will not qualify if you...
- Previously enrolled in this study
- Unable to understand the investigational nature of the study
- Having undergone more than three frozen embryo transfers
- Currently using oral or injectable corticosteroids
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Instituto Valenciano de Infertilidade (IVI Lisboa)
Lisbon, Portugal, 1800-282
Actively Recruiting
Research Team
S
Samuel Ribeiro
CONTACT
B
Belisa Silva
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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