Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07004699

Comparison of Two Ventilation Methods During Endoscopy of the Pharynx, Larynx and Oesophagus

Led by Poitiers University Hospital · Updated on 2026-02-27

610

Participants Needed

2

Research Sites

102 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Around 15,000 ENT cancers are diagnosed each year in France. The majority of these cancers will at one time or another require an Endoscopy of the Pharynx, Larynx and Esophagus (Endo-PLE or suspension laryngoscopy). Endoscopies of the Otorhinolaryngeal (ENT) sphere are common procedures. They consist of inserting a rigid laryngoscope through the mouth, allowing full exposure of the laryngeal sphere. They are performed in most cases as part of a swelling assessment, following CT scans, or following the discovery of a mass upon palpation of the patient. Unfortunately, these are aggressive cancers that subsequently require major surgery and additional treatment by radio or chemotherapy. This examination can also be performed on patients suffering from swallowing disorders, following the appearance of polyps, and this time not requiring an adjuvant to surgery but their removal. For all patients, these endo-PLE are performed in the operating room and require general anesthesia. This surgical procedure is now performed by performing two laryngoscopies. The first is used to maintain good pulmonary oxygenation by introducing an oxygen cannula, the second constitutes the surgical procedure itself. The oxygen cannula is placed through the nasal cavity, directly up to the entrance of the vocal cords. This procedure is not without risk both for the patient (risk of dental breakage and bleeding during laryngoscopy) but also for the surgeon, because the cannula itself can obstruct his vision. It would be possible to do without one of them by setting up high-flow oxygen therapy (HFOT). This device has been widely deployed in continuous care and intensive care units, but is not yet the subject of much research in surgical units. The HFOT consists of oxygen cannulae delivering a mixture of gases at a high flow rate ranging from 20 to 70 liters per minute. The investigator want to evaluate through this study, the feasibility and effectiveness of setting up HFOT during procedures. The evaluation of this benefit compared to the standard method will be done using several elements including the collection of continuous saturation and blood analysis of capillary samples pre-, per- and post-operatively.

CONDITIONS

Official Title

Comparison of Two Ventilation Methods During Endoscopy of the Pharynx, Larynx and Oesophagus

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient aged 18 or over
  • Not requiring oxygen
  • Scheduled for endoscopy of the pharynx, larynx, and esophagus surgery only
  • American Society of Anesthesiology score between 1 and 4
  • Signed informed consent
Not Eligible

You will not qualify if you...

  • Endoscopy of the pharynx, larynx, and esophagus surgery combined with another procedure
  • Severe or morbid obesity (BMI 65 35 kg/m�b2)
  • Stage IV chronic obstructive pulmonary disease
  • Allergy to remifentanil, propofol, or lidocaine

AI-Screening

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Trial Site Locations

Total: 2 locations

1

CHU Poitiers

Poitiers, France, 86000

Actively Recruiting

2

CHU de Poitiers

Poitiers, France, 86021

Not Yet Recruiting

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Research Team

G

Guillaume BEAUMATIN

CONTACT

R

Rémi DRILLEAU

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

OTHER

Number of Arms

2

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