Actively Recruiting
Comparison of Ultrasound Cerebral Perfusion Imaging With Routine Perfusion CT
Led by Resolve Stroke · Updated on 2026-01-07
50
Participants Needed
1
Research Sites
42 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary goal of neurocritical care is to prevent secondary brain injury, which worsens neurological outcomes. Because clinical monitoring is often insufficient due to the patient's condition and medical treatments, multimodal monitoring using biophysical, electrophysiological, and imaging data is essential. In patients with subarachnoid hemorrhage (SAH), the most frequent and severe complication is delayed cerebral ischemia, often linked to arterial vasospasm and potentially leading to infarction. Early diagnosis combines transcranial Doppler (TCD), sensitive to vasospasm, with perfusion CT (CTP), which measures cerebral perfusion; this approach guides therapy and improves prognosis. Ultrasound, especially when enhanced with contrast agents (CEUS), allows non-invasive, bedside, repeated visualization of cerebral blood flow and perfusion-even through the skull. Agents like SonoVue® help quantify perfusion using time-intensity curves. The study aims to assess whether cerebral perfusion measurements from the SYLVER device are equivalent to those from CTP in ICU or CCU patients.
CONDITIONS
Official Title
Comparison of Ultrasound Cerebral Perfusion Imaging With Routine Perfusion CT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient 18 years old or older
- Patient or relative has provided informed consent
- Admitted to ICU or CCU with indication for at least one perfusion CT scan
- Affiliated with or benefiting from a social security scheme
- Current clinical status does not require immediate emergency treatment at enrollment
You will not qualify if you...
- Under guardianship, curatorship, or deprived of liberty by judicial or administrative decision
- Pregnant or breastfeeding women
- Known allergy or hypersensitivity to SonoVue® or its components
- Presence of right-to-left heart shunts
- History of craniectomy in the temporal region
- Open wounds or recent scars in the temporal region
- Unstable hemodynamic or respiratory condition preventing transportation to CT perfusion scanner
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre Hospitalo-Universitaire Gui de Chauliac
Montpellier, Herault, France, 34000
Actively Recruiting
Research Team
V
Vivien Szabo, MD, PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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