Actively Recruiting

Phase Not Applicable
Age: 18Years - 75Years
All Genders
ID06243848

Comparison of Ultrasound-Guided Injection With Traditional Median Nerve Decompression Surgery in Patients With Carpal Tunnel Syndrome: Randomized Controlled Study

Led by Afyonkarahisar Health Sciences University · Updated on 2026-03-12

60

Participants Needed

1

Research Sites

4 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Carpal tunnel syndrome (CTS) is the most common type of nerve compression disorder, causing symptoms like numbness, tingling, pain, and weakness in the hand areas served by the median nerve. This research compares two treatments for people with mild to severe CTS: an ultrasound-guided injection around the median nerve and a traditional minimal incision surgery to relieve pressure on the nerve. The study aims to evaluate which approach better reduces symptoms and improves hand function. The study involves two treatment groups. One group will receive a minimal incision surgery where a small cut is made to relieve pressure on the median nerve by cutting the surrounding tissue. The other group will have an ultrasound-guided injection of 5 cc of 5% dextrose around the median nerve using a precise technique to reduce risk of injury. Both treatments target the same nerve but use different methods to reduce compression. Participants will be monitored throughout the study with assessments of wrist pain using a visual analog scale (VAS) at 4 and 12 weeks after treatment. Additional measurements include symptom questionnaires, nerve size by ultrasound, electrical nerve tests, and hand grip strength at the same time points. The study will track changes from baseline to understand each treatment’s impact on symptoms and nerve function over about three months.

CONDITIONS

Brief Title

Comparison of Ultrasound-Guided Injection With Median Nerve Decompression Surgery in Carpal Tunnel Syndrome

Who Can Participate

Age: 18Years - 75Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Symptoms such as nighttime, posture-related, or movement-related numbness or pain in the hand area served by the median nerve for more than 3 months
  • Diagnosis of mild, moderate, or severe carpal tunnel syndrome confirmed by nerve conduction tests
  • Numbness and loss of sensation in median nerve areas and weakness in thenar muscles
  • Positive Phalen test and/or Tinel sign indicating median nerve involvement
Not Eligible

You will not qualify if you...

  • Symptoms similar to carpal tunnel syndrome caused by cervical radiculopathy, polyneuropathy, brachial plexopathy, or thoracic outlet syndrome
  • Injection into the carpal tunnel within the past 6 months
  • Thenar muscle wasting (atrophy)
  • Previous carpal tunnel surgery
  • Regular use of systemic nonsteroidal anti-inflammatory drugs or corticosteroids
  • Pregnancy
  • Diagnosis of rheumatoid arthritis, systemic lupus erythematosus, gout, systemic sclerosis, dermatomyositis, or polymyositis
  • Cancer
  • Active infections

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Single treatment session with follow-up assessments up to 12 weeks

Participants receive either ultrasound-guided perineural injection or minimal incision surgery to relieve carpal tunnel syndrome symptoms.

1 treatment visit and 2 follow-up visits at 4 and 12 weeks

Trial Site Locations

Total: 1 location

1

Afyonkarahisar Health Sciences University

Afyonkarahisar, Turkey (Türkiye), 03200

Actively Recruiting

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Research Team

A

Ali İzzet AKÇİN, MD

N

Nuran EYVAZ, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Published Research Related To This Trial

Effect of Perineural Injection with Different Dextrose Volumes on Median Nerve Size, Elasticity and Mobility in Hands with Carpal Tunnel Syndrome.

Meng-Ting Lin, I-Chun Liu, Wei-Ting Syu...

https://pubmed.ncbi.nlm.nih.gov/34065073

Update on surgical procedures for carpal tunnel syndrome: What is the current evidence and practice? What are the future research directions?

Valerio Pace, Fabrizio Marzano, Giacomo Placella

https://pubmed.ncbi.nlm.nih.gov/36686281