A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill.
Jean-François Timsit, Mark Rupp, Emilio Bouza...
https://pubmed.ncbi.nlm.nih.gov/29754308Actively Recruiting
Phase Not Applicable
Age: 18Years - 80Years
All Genders
ID06635551
Comparison of Vascular Catheter-Related Thrombosis and Risk Factors Using Daily Bedside Ultrasonography After Oncologic and Non-Oncologic Major Surgery
Led by Mersin University · Updated on 2025-12-05
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to prospectively evaluate vascular catheter-related thrombosis (VCRT) and its risk factors in patients undergoing major surgery, both oncologic and non-oncologic. Vascular catheters are commonly used in critically ill patients and those having major surgery, but thrombosis related to these catheters can lead to complications like pulmonary embolism. The clinical significance of VCRT and its timing after catheter placement in surgical patients remains unclear, prompting this detailed investigation using daily ultrasound monitoring. The study compares two groups: cancer patients and non-cancer patients receiving central venous catheters during major surgery. Ultrasonography will be performed daily from before catheter insertion until catheter removal or ICU discharge to detect thrombosis presence, size, and progression. Key catheter details such as size, length, insertion site, and ultrasound guidance use will be recorded. Decisions about catheter removal or anticoagulation treatment will follow usual medical care. Participants will undergo daily ultrasound exams of veins near the catheter site to monitor for thrombosis using specific imaging criteria. Researchers will track the incidence and timing of thrombosis, thrombus size changes, related serious complications, hospital or ICU stay length, and mortality. The catheter will be monitored for at least 10 days when possible, with follow-up assessments extending up to 30 days for complications and up to 10 weeks for hospital outcomes.
CONDITIONS
Brief Title
Comparison of Vascular Catheter-Related Thrombosis and Risk Factors After Oncologic and Non-Oncologic Major Surgery
Who Can Participate
Age: 18Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Adult patient aged 18 to 80 years
- No hematological disease causing increased blood clotting
- Not currently receiving anticoagulant or antifibrinolytic medications at therapy doses
- Vascular structure can be clearly visualized with ultrasound
- No thrombosis detected by ultrasound before catheter placement
- Catheter is not placed for renal replacement therapy
You will not qualify if you...
- Presence of kidney failure
- Pediatric patients
- Presence of hematological malignancy
- Inadequate ultrasound imaging quality
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - For the duration of catheter stay, at least 10 days if possible
Participants receive a central venous catheter during major surgery and have daily ultrasound evaluations to detect vascular catheter-related thrombosis until the catheter is removed or the patient is discharged from the intensive care unit.
Daily visits for ultrasound assessment until catheter removal or discharge
Follow-up
Duration - Up to 30 days postoperatively for complications; up to 10 weeks for length of stay and mortality
Participants are monitored daily for severe complications related to catheter thrombosis and clinical outcomes including length of hospital stay and mortality.
Daily visits for up to 30 days; assessments up to 10 weeks
Trial Site Locations
Total: 1 location
1
Mersin University
Mersin, Yenişehir, Turkey (Türkiye), 33343
Actively Recruiting
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Research Team
L
Levent Özdemir
N
Nurcan Doruk
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Daily point-of-care ultrasound-assessment of central venous catheter-related thrombosis in critically ill patients: a prospective multicenter study.
Chunshuang Wu, Mao Zhang, Wenjie Gu...
https://pubmed.ncbi.nlm.nih.gov/36892598Venous thromboembolism associated with central venous catheters in patients with cancer: From pathophysiology to thromboprophylaxis, areas for future studies.
Philippe Debourdeau, Anne Lamblin, Théodore Debourdeau...
https://pubmed.ncbi.nlm.nih.gov/34363736