Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID05698589

Compassion Focused Therapy for Reducing Internalized Stigma in Mental Disorders: A Randomized Controlled Study

Led by University Hospital, Strasbourg, France ยท Updated on 2025-08-06

336

Participants Needed

7

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

People with mental disorders often face stigmatizing attitudes, which can lead them to isolate themselves and interfere with their care and recovery. This trial focuses on reducing self-stigma, a form of stigma individuals apply to themselves, which is linked to increased shame, lowered coping skills, social avoidance, and worse clinical outcomes. Compassion Focused Therapy (CFT), a type of cognitive behavioral therapy aimed at reducing shame and fostering self-compassion, is being evaluated for its effectiveness in individuals with high levels of self-stigma. The study compares three groups: one receiving group-based Compassion Focused Therapy, another undergoing a psychoeducation program called Ending Self Stigma (ESS), and a third receiving treatment as usual (TAU). The CFT program includes psychoeducation on compassion and emotion regulation, experiential exercises during sessions, and guided practices with video support between sessions. The ESS program provides education on stigma and self-stigma and encourages home exercises to improve self-esteem. Participants will be assessed for internalized stigma using the Internalized Stigma of Mental Illness inventory (ISMI) at the start and monthly for three months. The study involves psychiatric evaluations to monitor symptom severity and ensure safety. Researchers will evaluate changes in self-stigma levels and the acceptability of the treatments over the study period. The trial is sponsored by the University Hospital in Strasbourg, France, and is ongoing with a planned end date in March 2028.

CONDITIONS

Brief Title

COMpassion for Psychiatric Disorders And Self-Stigma

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient 18 years of age or older
  • Patient informed of the results of the preliminary medical examination
  • Patient affiliated with a social health insurance plan
  • Diagnosis of chronic psychiatric disorder (schizophrenia, schizoaffective disorder, bipolar disorder, recurrent major depression, borderline personality disorder) or neurodevelopmental disorder (autism spectrum disorder) treated as outpatient or day hospital
  • CGI-Severity score less than 6 and moderate to high self-stigma (ISMI score >2.5)
Not Eligible

You will not qualify if you...

  • Participation in an exclusion period from another study
  • Participation in an interventional study involving psychotherapy or experimental drug
  • Currently in an acute episode of the disorder (CGI Severity score)
  • Medical emergency or immediate life-threatening situation
  • Intellectual disability with IQ below 70
  • Under legal care constraints or deprived of freedom by judicial measure
  • Insufficient French language skills to participate

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Outpatient Treatment

Duration - 3 months

Participants receive behavioral therapy sessions focused on reducing self-stigma in mental disorders, including Compassion Focused Therapy or Ending Self Stigma program, with in-session experiential exercises and home practice assignments.

Weekly visits for therapy sessions

Trial Site Locations

Total: 7 locations

1

Pรดle de Psychiatrie Adulte, Hรดpital Charles Perrens

Bordeaux, France, 33076

Not Yet Recruiting

2

Ch Le Vinatier

Bron, France, 69678

Not Yet Recruiting

3

CHU de Clermont-Ferrand, Hรดpital Gabriel Montpied, Service de Psychiatrie B

Clermont-Ferrand, France, 63003

Not Yet Recruiting

4

Pรดle Hospitalo-Universitaire de Psychiatrie d'adultes et d'addictologie du Grand Nancy, Centre Psychothรฉrapique de Nancy

Laxou, France, 54520

Not Yet Recruiting

5

CHU de Montpellier, Psychiatrie d'adultes, Hรดpital la Colombiรจre

Montpellier, France, 34295

Not Yet Recruiting

6

Etablissement Public de Santรฉ Mentale (EPSM) de la Marne, Site Pierre-Briquet, Unitรฉ de rรฉhabilitation psychosociale

Reims, France, 51100

Not Yet Recruiting

7

Service de Psychiatrie, Hรดpital Civil, Hรดpitaux Universitaires de Strasbourg

Strasbourg, France, 67091

Actively Recruiting

Loading map...

Research Team

L

Luisa Weiner

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

Similar Trials

The Effects of Citalopram on the Brain's Response to Emotion...

Emotional Processing

Actively Recruiting

1 location

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Published Research Related To This Trial

Compassion-focused therapy (CFT) for the reduction of the self-stigma of mental disorders: the COMpassion for Psychiatric disorders, Autism and Self-Stigma (COMPASS) study protocol for a randomized controlled study.

M Riebel, O Rohmer, E Charles...

https://pubmed.ncbi.nlm.nih.gov/37309006