Actively Recruiting
Compassionate Use of Domperidone for Refractory Gastroparesis
Led by Jose Cocjin · Updated on 2026-03-24
20
Participants Needed
1
Research Sites
1182 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this program is to allow the use of domperidone in children from 12 to 21 years of age with symptoms related to motility disorders and Gastroesophageal reflux disease (GERD) who have failed all the standard treatments for their condition.
CONDITIONS
Official Title
Compassionate Use of Domperidone for Refractory Gastroparesis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female
- Age between 12 and 21 years
- Symptoms related to GERD or gastrointestinal motility disorders such as persistent esophagitis, heartburn, nausea, vomiting, severe dyspepsia, or severe chronic constipation that have not responded to standard therapy
- Comprehensive evaluation completed to rule out other causes of symptoms
- Signed informed consent acknowledging potential adverse effects including increased prolactin levels, extrapyramidal side effects, breast changes, cardiac arrhythmias including QT prolongation, and risks related to certain medications and herbal supplements
You will not qualify if you...
- History or current presence of serious arrhythmias such as ventricular tachycardia, ventricular fibrillation, or Torsade des Pointes (minor arrhythmias like PACs may be allowed)
- Clinically significant bradycardia, sinus node dysfunction, or heart block; QTc prolongation over 450 ms for males or 470 ms for females
- Significant electrolyte imbalances
- Gastrointestinal hemorrhage or obstruction
- Presence of a prolactinoma (pituitary tumor releasing prolactin)
- Pregnant or breastfeeding females
- Known allergy to domperidone
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children's Mercy Hospitals and Clinics
Kansas City, Missouri, United States, 64108
Actively Recruiting
Research Team
C
Corey Schurman, MA, CCRC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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