Comparative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation on Upper Limb Function, Cognition and Quality of Life in Subacute Stroke Patients

What this Trial Is About

This research aims to evaluate whether transcutaneous vagus nerve stimulation (tVNS) applied via the auricular or cervical branches can improve recovery when combined with task-specific training in patients who have had a subacute stroke. The study focuses on upper limb motor function and cognitive areas such as attention, memory, and executive function. It also seeks to understand how each stimulation method may enhance quality of life, providing valuable guidance for clinical rehabilitation of stroke survivors. Participants are divided into two groups: one group receives tVNS through the auricular branch using TENS applied at the ear level with clip electrodes, and the other group receives tVNS through the cervical branch with pad electrodes applied to the neck. Both groups perform task-specific exercises including grip and release tasks, reaching activities, bilateral arm movements, and tabletop activities. Treatments last 30 minutes per session, five days a week, for eight consecutive weeks. Throughout the study, participants undergo assessments at baseline, after 4 weeks, and after 8 weeks. These include tests for upper limb function (Fugl-Meyer Assessment, Wolf Motor Function Test), cognitive abilities (Montreal Cognitive Assessment), and quality of life (Stroke-Specific Quality of Life Scale). The study involves randomized assignment and double masking to compare the effects of the two stimulation methods on recovery. Safety and progress are monitored throughout the treatment and follow-up periods.

Comperative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation in Subacute Stroke Patients