Study of Gut Bacteria Differences in People With and Without Metastatic Colorectal Cancer Collecting Tissue and Stool Samples to Understand Cancer Spread

What this Trial Is About

Colorectal cancer is a common and serious disease that often spreads to other parts of the body. This research focuses on understanding how bacteria in the gut and within tumors may affect the spread of colorectal cancer. Investigators aim to discover differences in bacteria between patients whose cancer has spread and those whose cancer has not, and whether certain bacteria can help predict cancer spread. Participants are divided into groups including healthy individuals, patients with colorectal cancer without distant metastasis, and patients with metastatic colorectal cancer. Samples collected include stool samples, tumor tissue, normal tissue near tumors, and tissue from metastatic sites. These samples will be analyzed to compare bacterial patterns among the groups. During the study, participants will provide stool samples and tissue samples during surgery if applicable. Researchers will study the diversity of intestinal bacteria using advanced testing. The main measurement is the difference in microbiota diversity between patients with and without peritoneal metastasis. All specimens are collected and analyzed within six months after surgery. Participation involves sample collection and may last throughout the surgical and initial hospital admission period.

Comprehensive Analysis of Gut Microbiota Signatures in Metastatic Colorectal Cancer