Actively Recruiting
Comprehensive Assessment of Morphometric, Functional, Biomechanical and Biological Interactions Between Atherosclerotic Plaque and Platelets Within the Stenosed Coronary Artery
Led by Medical University of Warsaw · Updated on 2024-02-23
105
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
M
Medical University of Warsaw
Lead Sponsor
N
National Science Centre, Poland
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main objective of the present study is to verify, in vivo, whether shear forces computed solely based on coronary angiography and computational fluid dynamics (CFD) techniques are associated with the biomarkers indicating the prothrombotic tendency of circulating blood in situ - distally and proximally to the coronary stenosis. The study will prospectively assess the relationship between i) the value and distribution of shear rate and shear stress (SS) estimated using three-dimensional angiography and CFD techniques, and ii) atherosclerotic plaque characteristics as assessed by optical coherence tomography (OCT), iii) functional parameters of diseased vessels assessed by vessel fractional flow reserve (vFFR), and iv) in situ platelet activation, as expressed by platelet-derived microvesicles (pMVs) and small extracellular vesicles (sEVs), platelet aggregometry and other serum prothrombotic or inflammatory biomarkers sampled within the coronary artery.
CONDITIONS
Official Title
Comprehensive Assessment of Morphometric, Functional, Biomechanical and Biological Interactions Between Atherosclerotic Plaque and Platelets Within the Stenosed Coronary Artery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Chronic coronary syndrome
- Coronary artery narrowing between 30% and 90% confirmed by angiography
- Coronary artery suitable for OCT imaging as judged by the operator
You will not qualify if you...
- Cardiogenic shock
- ST-segment elevation or non-ST-segment elevation myocardial infarction
- Active bleeding
- Disease of the left main coronary artery
- Disease affecting multiple coronary vessels
- Lesions located 3 mm or closer to the vessel opening
- Low platelet count (thrombocytopenia)
- Previous coronary artery bypass grafting
- Previous coronary intervention with stent implantation or balloon angioplasty
- Previous use of novel oral anticoagulants or vitamin K antagonists
AI-Screening
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Trial Site Locations
Total: 1 location
1
Medical University of Warsaw
Warsaw, Masovian Voivodeship, Poland, 02-097
Actively Recruiting
Research Team
M
Mariusz Tomaniak
CONTACT
A
Adrian Bednarek
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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