Actively Recruiting
A Comprehensive Clinical fMRI Software Solution to Enable Mapping of Critical Functional Networks and Cerebrovascular Reactivity in the Brain
Led by M.D. Anderson Cancer Center · Updated on 2025-11-14
1720
Participants Needed
1
Research Sites
236 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Our preliminary work demonstrates that an integrated fMRI software solution, incorporating tb-fMRI, rs-fMRI, and CVR mapping, is clinically feasible and helps clinicians plan brain tumor resection. We have developed a novel automated seed selection method that can accurately map language networks from rs-fMRI. We hypothesize that our innovative approach to enhance, optimize, and validate our preliminary software and integrate it with an established fMRI platform will create robust solutions for clinical RSN and CVR mapping. Partnering with NordicNeuroLab (NNL) will leverage the professional software development by a seasoned commercial MRI software producer in coordination with leading clinical and research experts at MD Anderson. The research will be conducted through three specific aims: 1. Develop a clinical software platform for mapping RSNs and determine optimized workflow for presurgical localization of eloquent areas. 2. Develop a clinical software platform for mapping CVR and determine optimized workflow for identifying and visualizing brain areas with potential false-negative fMRI results. 3. Test and validate RSN and CVR mapping software in patients undergoing neurosurgery.
CONDITIONS
Official Title
A Comprehensive Clinical fMRI Software Solution to Enable Mapping of Critical Functional Networks and Cerebrovascular Reactivity in the Brain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must be 18 years or older
- Patients scheduled for neurosurgical resection of brain tumors
- Patients who will have presurgical fMRI as part of standard care
- Patients planned for direct cortical stimulation during neurosurgery
You will not qualify if you...
- Patients unable to give informed consent
- Patients unable to undergo MRI examinations
- Patients indicated for speech fMRI only but unable to perform speech tasks as evaluated by a neuropsychologist
- Retrospective fMRI scans with excessive head motion (translation > 2 mm or rotation > 2 degrees)
- Retrospective patients who only had speech fMRI paradigms and could not comply with speech tasks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
H
Ho-Ling Liu, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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