Actively Recruiting
Comprehensive Coronary Physiology in Patients With Angina With Nonobstructive Coronary Arteries - Czech Republic
Led by University Hospital, Motol · Updated on 2025-08-05
1000
Participants Needed
1
Research Sites
349 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Motol
Lead Sponsor
S
St. Anne's University Hospital Brno, Czech Republic
Collaborating Sponsor
AI-Summary
What this Trial Is About
Coronary artery disease (CAD) is a leading cause of morbidity and mortality. While cardiologists have been focused on discrete, visible stenoses of coronary arteries, there is increasing awareness of the importance of microcirculation and vasospastic disorders in causing angina. The microvascular bed is composed of vessels smaller than 400 microns in diameter. Their network is significantly larger than that of the epicardial vessels and serves essential functions, including regulating myocardial blood flow and cellular metabolism. Angina pectoris, a most frequent symptom of CAD or myocardial ischemia, was assumed to be caused by significant stenosis of the epicardial coronary artery. However, it was found that in over 50% of cases, there was no obstructive CAD, which is described as angina with no obstructive coronary arteries (ANOCA) or ischemia with no obstructive coronary arteries (INOCA), according to the clinical setting.
CONDITIONS
Official Title
Comprehensive Coronary Physiology in Patients With Angina With Nonobstructive Coronary Arteries - Czech Republic
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults of both sexes older than 18 years
- Presence of angina symptoms or angina equivalent
- Referred to a catheterization lab for coronary artery disease evaluation
- Underwent invasive physiology testing including microcirculation testing with or without vasospasm testing
You will not qualify if you...
- Under 18 years of age
- Pregnant or nursing women
- No coronary physiology measurements performed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Motol
Prague, Česká Republika, Czechia, 15006
Actively Recruiting
Research Team
P
Petr Kala, M.D., Ph.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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