Comprehensive Coronary Physiology Evaluation for Adults With Angina and No Blockage in Coronary Arteries in the Czech Republic

What this Trial Is About

Coronary artery disease CAD is a major cause of illness and death, with angina being a common symptom. Researchers are focusing on the role of small blood vessels in the heart, called the microcirculation, and vasospastic disorders, which can cause angina even when larger coronary arteries are not blocked. This study aims to better understand different types of angina with no obstructive coronary arteries ANOCA, including microvascular angina and vasospastic angina, by using advanced invasive coronary function tests. The study evaluates patients referred for invasive coronary physiology testing to assess both epicardial and microcirculatory artery function. Testing includes coronary angiography, measurement of blood flow and resistance using temperature-pressure wires, and acetylcholine testing to detect vasospasm. This comprehensive coronary functional testing helps identify specific ANOCA endotypes, such as microvascular dysfunction or vasospastic angina, which guide tailored treatment approaches. The study also investigates the relationship between epicardial adipose tissue measured by cardiac magnetic resonance imaging and microvascular dysfunction. Participants undergo invasive testing in a catheterization laboratory, with follow-up visits to assess treatment changes and cardiovascular outcomes over time. Researchers will monitor all-cause death and major adverse cardiovascular events MACE at one year. The study collects detailed data on patient selection, procedures, treatments, and outcomes to improve understanding and management of patients with angina without obstructive coronary artery disease.

Comprehensive Coronary Physiology in Patients With Angina With Nonobstructive Coronary Arteries - Czech Republic